Issues
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Cover image
Cover Image
Cover: Knocking out a single gene in Lymnaea stagnalis reverses snail coiling. Image shows the wild-type dextral snail (right) and a CRISPR-created sinistral snail (left), which is the 5th generation from an Lsdia1 knockout embryo, 8-F5 (ins1/ins1), in an otherwise totally dextral genetic background. Image courtesy of Dr Hiromi Takahashi of the Kuroda laboratory. See research article by Abe and Kuroda (dev175976).
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RESEARCH HIGHLIGHTS
OBITUARY
Sydney Brenner: a master of science and of wit
Summary: Peter Lawrence reflects on the life and work of Sydney Brenner – ‘the Oscar Wilde of science’.
INTERVIEWS
MEETING REVIEW
Repair, regenerate and reconstruct: meeting the state-of-the-art
Summary: Research reported at the seventh EMBO meeting on the Molecular and Cellular Basis of Regeneration and Tissue Repair included important discoveries on regeneration and provided perspectives for regenerative medicine.
PRIMER
The cytoneme connection: direct long-distance signal transfer during development
Summary: During development, specialized cells produce signals that are distributed among receiving cells to induce a variety of cellular behaviors and organize tissues. This Primer discusses how the dynamic regulation of cytonemes facilitates such signal transfer.
REVIEW
The origins and non-canonical functions of macrophages in development and regeneration
Summary: This Review discusses current knowledge of the developmental origins of various macrophage populations and the non-canonical functions of macrophages in development, regeneration and tissue repair.
STEM CELLS AND REGENERATION
Rapid clearance of cellular debris by microglia limits secondary neuronal cell death after brain injury in vivo
Summary: Zebrafish microglia help to prevent the spread of tissue damage in the aftermath of a brain injury by migrating to the lesion site and clearing it of dead cells.
The ciliary GTPase Arl3 maintains tissue architecture by directing planar spindle orientation during epidermal morphogenesis
Summary: The ciliary GTPase Arl3 is required to maintain mitotic spindle orientation and planar cell polarity signaling during skin development, processes that are crucial to the maintenance of epithelial architecture.
The Shh receptor Boc is important for myelin formation and repair
Summary: The Sonic hedgehog receptor Boc is implicated in oligodendrogenesis and axon calibre regulation during development, and participates in microglia and/or macrophage transition from highly to faintly ramified morphology during myelin repair.
RESEARCH REPORT
The development of CRISPR for a mollusc establishes the formin Lsdia1 as the long-sought gene for snail dextral/sinistral coiling
Highlighted Article: CRISPR/Cas9 reveals that Lsdia1 is the gene that determines the body handedness of Lymnaea stagnalis from the undifferentiated one-cell stage, through the decisive 3rd cleavage and via the nodal and Pitx pathways.
RESEARCH ARTICLES
A dual function of FGF signaling in Xenopus left-right axis formation
Summary: FGF signaling induces and patterns the frog left-right organizer in the early gastrula and regulates the morphogenesis of the flow sensor following specification of the precursor tissue.
Activation of butterfly eyespots by Distal-less is consistent with a reaction-diffusion process
Highlighted Article: CRISPR-generated mutants and theoretical modeling show that Dll is a crucial activator of butterfly wing eyespot center differentiation.
Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule
Summary: In the Malpighian tubules, GATAe is necessary not only for the morphology and function of the tubule but for the integrative physiology of the animal as a whole.
Myocardial differentiation is dependent upon endocardial signaling during early cardiogenesis in vitro
Highlighted Article: Interaction between endocardial cells and cardiomyocytes during the initial stages of in vitro cardiac differentiation promotes myocardial differentiation and maturation through the BMP signaling pathway.
The transmembrane protein Crb2a regulates cardiomyocyte apicobasal polarity and adhesion in zebrafish
Highlighted Article: Investigation of the Crumbs polarity protein Crb2a in zebrafish reveals a novel role in cardiac development via regulation of cell-cell adhesion and apicobasal polarity.
Yap and its subcellular localization have distinct compartment-specific roles in the developing lung
Highlighted Article: Hippo-Yap has several roles during lung development. We define these roles and show how they change with developmental age and the location of a cell along the proximal-distal axis of the lung.
A Cut/cohesin axis alters the chromatin landscape to facilitate neuroblast death
Summary: Cut regulates the programmed death of neural stem cells by altering cohesin levels and promoting a more open chromatin conformation to allow cell death gene expression.
Paxillin-dependent regulation of apical-basal polarity in mammary gland morphogenesis
Summary: During mammary gland morphogenesis, paxillin regulates HDAC6 activity and microtubule acetylation to control cell polarization, cell shape and ductal branching.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.