Issues
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Cover image
Cover Image
Cover: Cell heterogeneity in human epicardium derived from human pluripotent stem cells is demonstrated by the heterogeneous expression of the transcription factor WT1 (magenta) under immunofluorescence imaging. The ZO-1 labelling (green) highlights the epithelial cobblestone structure that is characteristic of the epicardial tissue. Nuclei are labelled with DAPI (blue). See Research article by Gambardella et al. (dev174441)
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RESEARCH HIGHLIGHTS
INTERVIEW
SPOTLIGHT
Wolpert's French Flag: what's the problem?
Summary: This Spotlight discusses how and why Wolpert introduced the French Flag metaphor into developmental biology, but how his original idea was probably oversimplified by the community.
REVIEW
Positional information and tissue scaling during development and regeneration
Summary: Tissue proportions can adjust to altered cell numbers. This Review discusses scaling mechanisms from a molecular and mathematical perspective.
HUMAN DEVELOPMENT
Naïve human pluripotent stem cells respond to Wnt, Nodal and LIF signalling to produce expandable naïve extra-embryonic endoderm
Highlighted Article: Exploiting naïve human embryonic stem cells, this study generates an in vitro model for primitive endoderm, its expansion, and demonstrates a conserved role for FGF/ERK signalling in its induction.
BNC1 regulates cell heterogeneity in human pluripotent stem cell-derived epicardium
Highlighted Article: Single cell analysis of human pluripotent stem cell-derived epicardium revealed that epicardial heterogeneity is regulated by the transcription factor BNC1 and separates the cells into two populations with different properties.
STEM CELLS AND REGENERATION
Lar maintains the homeostasis of the hematopoietic organ in Drosophila by regulating insulin signaling in the niche
Summary: Lar limits insulin signaling to regulate the size and activity of the larval hematopoietic niche in Drosophila.
The Paf1 complex and P-TEFb have reciprocal and antagonist roles in maintaining multipotent neural crest progenitors
Highlighted Article: Polymerase-associated factor 1 complex function is required to maintain the neural crest progenitor population in zebrafish.
RESEARCH ARTICLES
The histone demethylase KDM5 controls developmental timing in Drosophila by promoting prothoracic gland endocycles
Summary: Identification of KDM5 as a new transcriptional regulator of the MAPK signaling cascade provides insights into the molecular mechanisms governing the regulation of ecdysone production and developmental growth control.
PRDM1 controls the sequential activation of neural, neural crest and sensory progenitor determinants
Summary: PRDM1 mediates transcriptional activation of neural and sensory progenitor genes by recruiting histone demethylases such as Kdm4a to their promoters, but must then be repressed to maintain neural, neural crest and placode cell fates.
E3 ubiquitin ligase MDM2 acts through p53 to control respiratory progenitor cell number and lung size
Summary: The MDM2-p53 axis determines lung progenitor cell number and subsequent organ size, but not airway patterning and cell differentiation.
A biphasic role of non-canonical Wnt16 signaling during early anterior-posterior patterning and morphogenesis of the sea urchin embryo
Summary: Non-canonical Wnt16 signaling is essential for establishing the position of the early germ layer gene regulatory networks along the anterior-posterior axis, and activates molecular mechanisms necessary for gastrulation and mesenchyme morphogenesis.
The plakin domain of C. elegans VAB-10/plectin acts as a hub in a mechanotransduction pathway to promote morphogenesis
Summary: CRISPR-derived deletions reveal the roles of distinct domains from the hemidesmosome sprectraplakin VAB-10 in mechanotransduction during C. elegans morphogenesis.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.