DEVELOPMENT AT A GLANCE
Summary: This Meeting Review discusses how recent technological advances have impacted the study of cell types and how this might change our view of cell type identity and evolution.
STEM CELLS AND REGENERATION
The p75 neurotrophin receptor is required for the survival of neuronal progenitors and normal formation of the basal forebrain, striatum, thalamus and neocortex
Summary: Conditional knockout of p75NTR in mouse neuronal progenitors results in variable effects on the brain, including a marked decrease in brain volume and impaired thalamic midline closure.
Partially overlapping guidance pathways focus the activity of UNC-40/DCC along the anteroposterior axis of polarizing neuroblasts
Summary: The left-right asymmetric polarization of the C. elegans Q neuroblasts is mediated through a ligand-independent mechanism that localizes the netrin receptor UNC-40/DCC at the anterior or posterior side of the cell.
Summary: The Drosophila polarity proteins Scribble and Discs Large are key components of the tricellular junction protein complex along with Gliotactin and Bark Beetle.
Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis
Summary: A strong genetic interaction between Tbx1 and Pax9 that leads to 4th PAA-derived defects in double heterozygous mice is cell-autonomous within the pharyngeal endoderm.
Summary: An integrated genomic approach identifies Shh-responsive genes and associated regulatory sequences with known and previously uncharacterized roles in cochlear morphogenesis, including genes that prime the cochlea for sensory development.
Downregulation of homeodomain protein Cut is essential for Drosophila follicle maturation and ovulation
Summary: A pathway with a complex transcriptional network, including multiple conserved factors, is necessary for final maturation of Drosophila ovarian follicle cells, which is essential for ovulation.
Summary: Genetic studies reveal that transcriptional autoregulation maintains the expression of tbx6 in the presomitic mesoderm of zebrafish embryos.
Summary: CD40L, a novel physiological regulator of early sensory axon growth at the stage when sensory axons are growing to their targets, activates CD40 forward signalling by target-derived and autocrine mechanisms.
TECHNIQUES AND RESOURCES
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
Highlighted Article: A new database generated using data from the systematic analysis of pattern formation, proliferation and growth in wild-type and scrib mutant wing imaginal discs: a neoplastic tumor model.