Issues
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Cover image
Cover Image
Cover: Fluorescence image of a Drosophila wing imaginal disc (dorsal side down) showing normal expression and distribution of total Wingless protein (green), its receptor Frizzled2 (blue) and a long-range Wingless signaling target Distal-less (magenta). See Research article by Chaudhary et al. (dev174789).
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RESEARCH HIGHLIGHTS
DEVELOPMENT AT A GLANCE
PIN-FORMED and PIN-LIKES auxin transport facilitators
Summary: This Development at a Glance article gives an overview of the structure, function and regulation of the PIN and PILS families of auxin transport facilitators.
REVIEWS
The molecular mechanisms mediating mammalian fertilization
Summary: This Review summarizes the precise molecular mechanisms regulating mammalian gamete recognition and fusion, and the block to polyspermy that ensures monospermic fertilization, which is essential for successful embryo development.
Hematopoietic stem cell-independent hematopoiesis and the origins of innate-like B lymphocytes
Summary: This Review summarizes the development of fetal immune cells that occurs before and after the appearance of the first bona fide hematopoietic stem cell in the embryo, and the possibility that certain tissue-resident immune cells in adults develop through an alternative pathway.
STEM CELLS AND REGENERATION
Wound-induced polyploidization is driven by Myc and supports tissue repair in the presence of DNA damage
Summary: Wound-induced polyploidization in the Drosophila epithelium is dependent on Myc and enables tissue repair in the presence of DNA damage when cell division is not a viable option.
RESEARCH ARTICLES
Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes
Summary: Mammalian Dmrt factors orchestrate the development of the dorsal telencephalon, a primordium of the cerebral cortex, via dose-dependent suppression of developmental patterning factors such as Pax6 and Gsx2.
Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs
Summary: During epithelia morphogenesis in Drosophila, the Rho-GTPase Cdc42 confers apical identity, Par-complex assembly and Crb accumulation to promote epithelial morphogenesis.
Integration of Wnt and FGF signaling in the Xenopus gastrula at TCF and Ets binding sites shows the importance of short-range repression by TCF in patterning the marginal zone
Highlighted Article: FGF and Wnt combinatorially regulate downstream genes, but differences in chromatin binding patterns of β-catenin and Ets may explain the differences in downstream target gene expression patterns.
The Egalitarian binding partners Dynein light chain and Bicaudal-D act sequentially to link mRNA to the Dynein motor
Summary: An shRNA depletion strategy has uncovered the role of Dlc in the dimerization of Egl, further revealing a step-wise assembly pathway for building a localization-competent mRNP.
Secondary crest myofibroblast PDGFRα controls the elastogenesis pathway via a secondary tier of signaling networks during alveologenesis
Summary: A cell-targeted genetic approach has revealed a previously unrecognized role of the PDGFA/PDGFRa axis, mediated through a complex and interdependent cross regulatory network of multiple signaling pathways that converge to regulate postnatal alveologenesis.
Robust Wnt signaling is maintained by a Wg protein gradient and Fz2 receptor activity in the developing Drosophila wing
Highlighted Article: Measuring the direct range of action of the Wg gradient reveals that Wg morphogen signaling in the growing epithelia is regulated by both long-range gradient-dependent and gradient-independent mechanisms.
FGF signaling patterns cell fate at the interface between tendon and bone
Summary: FGF signaling is essential in establishing the graded transitional tissue of the tendon-bone attachment unit by regulating cell fate decisions and the development of Scx+/Sox9+ cells.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.