Issues

Summary: Silvia Arber and James Briscoe look back at the life and career of Thomas M. Jessell who revolutionized our understanding of the mechanisms controlling neural tube development and circuit formation.

Summary: This Review describes the trafficking mechanisms proposed to mediate the extracellular transport of Wnt proteins and discusses how they contribute to Wnt dispersal.

Summary: This Review discusses recent structural and biochemical studies that have advanced our understanding of the vertebrate hedgehog pathway, a cell-cell communication system that plays important roles in development and disease.

Summary: A protocol that efficiently produces neuromesodermal progenitors from a multipotent population with progenitors for a variety of mesodermal derivatives.

Summary: Arabidopsis MED30 is essential not only for allele transmission through the male gametophyte, but also for embryo and seed development, later promoting phase transitions during subsequent developmental stages.

Summary: Niemann-Pick disease family protein (NPC1a) is involved in embryonic germ cell migration and Hedgehog signaling in Drosophila melanogaster.

Summary: A temporal regulation of protein synthesis by Lin28 in early brain development.

Summary: Cell sorting identifies limb bud mesenchymal progenitors (LMPs) with distinct molecular signatures and differential dependence on morphogen signaling. Specifically, two immature LMP populations with strong chondrogenic differentiation potential are identified.

Highlighted Article: An interdisciplinary approach reveals that the CELLULOSE SYNTHASE complex influences both physical and biological processes at the shoot apical meristem.

Summary: A novel nuclear inhibitor holds Tcf7l1 in a transcriptional inhibitory state and promotes silencing of Wnt target genes.

Summary: Removal of all PXY and ER gene family members results in profound cell division and organisation defects in Arabidopsis vascular tissue.

Summary: Maternal cell fate decisions in vertebrate embryos rely upon a specific set of molecular interactions between the evolutionarily conserved Bicaudal-C protein and its mRNA targets.

Summary: In vivo examination of long-distance migrations of zebrafish muscle precursors reveals how these cells are specified prior to migration and organized during migration to generate four hypaxial muscles.