Summary: This Review discusses recent structural and biochemical studies that have advanced our understanding of the vertebrate hedgehog pathway, a cell-cell communication system that plays important roles in development and disease.
STEM CELLS AND REGENERATION
Summary: A protocol that efficiently produces neuromesodermal progenitors from a multipotent population with progenitors for a variety of mesodermal derivatives.
The MED30 subunit of mediator complex is essential for early plant development and promotes flowering in Arabidopsis thaliana
Summary: Arabidopsis MED30 is essential not only for allele transmission through the male gametophyte, but also for embryo and seed development, later promoting phase transitions during subsequent developmental stages.
Functional analysis of Niemann-Pick disease type C family protein, NPC1a, in Drosophila melanogaster
Summary: Niemann-Pick disease family protein (NPC1a) is involved in embryonic germ cell migration and Hedgehog signaling in Drosophila melanogaster.
Lin28-mediated temporal promotion of protein synthesis is crucial for neural progenitor cell maintenance and brain development in mice
Summary: A temporal regulation of protein synthesis by Lin28 in early brain development.
Molecular signatures identify immature mesenchymal progenitors in early mouse limb buds that respond differentially to morphogen signaling
Summary: Cell sorting identifies limb bud mesenchymal progenitors (LMPs) with distinct molecular signatures and differential dependence on morphogen signaling. Specifically, two immature LMP populations with strong chondrogenic differentiation potential are identified.
Highlighted Article: An interdisciplinary approach reveals that the CELLULOSE SYNTHASE complex influences both physical and biological processes at the shoot apical meristem.
Barhl2 maintains T cell factors as repressors and thereby switches off the Wnt/β-Catenin response driving Spemann organizer formation
Summary: A novel nuclear inhibitor holds Tcf7l1 in a transcriptional inhibitory state and promotes silencing of Wnt target genes.
Organ-specific genetic interactions between paralogues of the PXY and ER receptor kinases enforce radial patterning in Arabidopsis vascular tissue
Summary: Removal of all PXY and ER gene family members results in profound cell division and organisation defects in Arabidopsis vascular tissue.
A single KH domain in Bicaudal-C links mRNA binding and translational repression functions to maternal development
Summary: Maternal cell fate decisions in vertebrate embryos rely upon a specific set of molecular interactions between the evolutionarily conserved Bicaudal-C protein and its mRNA targets.
Summary: In vivo examination of long-distance migrations of zebrafish muscle precursors reveals how these cells are specified prior to migration and organized during migration to generate four hypaxial muscles.