Neuronal migration in the CNS during development and disease: insights from in vivo and in vitro models
Summary: This Review discusses the mechanisms that regulate neuronal migration and associated disorders, with particular focus on appropriate in vivo and in vitro model systems.
Reproducibility and staging of 3D human retinal organoids across multiple pluripotent stem cell lines
Summary: Live morphological staging reveals common strengths and limitations of differentiating 3D retinal organoid cultures across multiple human pluripotent stem cell lines.
STEM CELLS AND REGENERATION
Highlighted Article: A single bifacial stem cell that is characterized by the combined activity of PXY (TDR), SMXL5 and WOX4 genes generates both wood and bast during radial plant growth.
Highlighted Article: Transcriptional profiling of dividing cells during early limb regeneration reveals an immunomodulatory role for blastemal progenitors through il-8/cxcr-1/2 signaling.
A Notch-regulated proliferative stem cell zone in the developing spinal cord is an ancestral vertebrate trait
Highlighted Article: Vertebrates develop nervous systems with numerous cells. Study of cell proliferation in the lamprey nervous system links this to the evolution of a ventricular proliferation zone regulated by Notch signalling.
Two functionally redundant sources of retinoic acid secure spermatogonia differentiation in the seminiferous epithelium
Summary: All-trans retinoic acid made by Sertoli cells is instrumental to spermatogenesis and is specifically required for spermatid release.
Transcriptionally dynamic progenitor populations organised around a stable niche drive axial patterning
Summary: During anteroposterior axis elongation, neuromesodermal and lateral mesoderm axial progenitors undergo dynamic transcriptomic change, while the adjacent notochord progenitors are stable and coordinate elongation.
Summary: Genetic and biochemical studies revealed an unusual mechanism by which targeted protein degradation regulates and remodels the specialized ring canal cytoskeleton during Drosophila development.
New roles of NO TRANSMITTING TRACT and SEEDSTICK during medial domain development in Arabidopsis fruits
Summary: The transcription factors NTT and STK control enzyme- and transporter-encoding genes involved in cell wall polysaccharide and lipid distribution in gynoecial medial domain cells in Arabidopsis.
Summary: Microtubule motor proteins kinesin and dynein directly carry yolk syncytial nuclei along microtubules towards the vegetal pole, mediated by the LINC complex, which acts as an adaptor between nuclei and motor proteins.
TECHNIQUES AND RESOURCES
Summary: A clonal analysis approach based on CRISPR-mediated excision, which allows control over the frequency of clonal labelling, is proposed and tested in the beetle Tribolium castaneum.