Issues
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Cover image
Cover Image
Cover: A three-dimensional reconstruction of the developing vasculature in a P4 murine retina. GFP-labelled late neuroprogenitor cells (green) are seen closely interacting with dividing isolectin B4-positive endothelial cells (white) at the angiogenic front of the superficial plexus, by means of their apical projections. See Research article by Cristante et al. (dev157511).
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RESEARCH HIGHLIGHTS
SPOTLIGHT
An interview with Christiana Ruhrberg
Summary: Christiana Ruhrberg, the winner of the British Society for Developmental Biology's Cheryll Tickle Medal, discusses her research trajectory from cancer to neurovascular development and her thoughts on the position of women in the field.
PRIMER
p53: emerging roles in stem cells, development and beyond
Summary: This Primer provides an overview of the roles of p53 in development and stem cells, and highlights how these relate to its well-known functions in tumor suppression.
REVIEW
The role of mitochondria in stem cell fate and aging
Summary: This Review looks beyond the role of mitochondria in cellular energy metabolism and highlights recent studies that implicate mitochondrial function in stem cell activation, fate decisions and defense against senescence.
STEM CELLS AND REGENERATION
Lmx1a is required for the development of the ovarian stem cell niche in Drosophila
Summary: The conserved transcription factor Lmx1a is required for the formation of terminal filaments in the Drosophila ovary during the larval-pupal transition and is essential for establishment of the stem cell niche.
Heterogeneous fates and dynamic rearrangement of regenerative epidermis-derived cells during zebrafish fin regeneration
Summary: The fate of regenerative epidermis cells during zebrafish fin regeneration has been elucidated: they transiently contribute to the regenerated epidermis, but many are expelled by dynamic epidermal rearrangement.
RESEARCH REPORT
Control of the proportion of inner cells by asymmetric divisions and the ensuing resilience of cloned rabbit embryos
Summary: A unique quantitative approach based on complete reconstruction of the cell lineage that unveils an unknown mechanism of size control in cell populations of rabbit blastocysts, wild types or clones.
RESEARCH ARTICLES
Late neuroprogenitors contribute to normal retinal vascular development in a Hif2a-dependent manner
Summary: Hypoxia-inducible factor 2a expressed in neuroprogenitors promotes angiogenesis in mouse retina by upregulating expression of vascular endothelial growth factor and erythropoietin, and downregulating endostatin.
Suppression of epithelial folding at actomyosin-enriched compartment boundaries downstream of Wingless signalling in Drosophila
Highlighted Article: In the Drosophila embryo, Wingless signalling is required to maintain robust actomyosin enrichment at parasegmental boundaries, and suppresses epithelial folding along these boundaries, where Hedgehog signalling has opposing effects.
Successive duplication-divergence mechanisms at the RCO locus contributed to leaf shape diversity in the Brassicaceae
Summary: Cis-regulatory diversification among RCO paralogs has resulted in the evolution of a three-gene cluster, in which each member regulates distinct aspects of leaf margin patterning.
The DEAD-box RNA helicase Ddx39ab is essential for myocyte and lens development in zebrafish
Summary: Ddx39ab is required for pre-mRNA splicing of KMT2 histone methyltransferases, with ddx39ab mutants failing to establish the epigenetic status required for terminal differentiation of cardiomyocyte, myoblast and lens fiber cell lineages.
Conserved and divergent functions of Pax6 underlie species-specific neurogenic patterns in the developing amniote brain
Highlighted Article: Pax6 promotes neuronal differentiation in the developing chick and mouse telencephalon via Notch inhibition, whereas its stage-specific function in RGC maintenance in the VZ is unique to mammalian neocortical progenitors.
Coordinated directional outgrowth and pattern formation by integration of Wnt5a and Fgf signaling in planar cell polarity
Summary: During mouse limb morphogenesis, Wnt5a plays both instructive and permissive roles in regulating planar cell polarity by orienting PCP itself, and by allowing apical ectoderm ridge-derived Fgfs to orient PCP.
CORRECTION
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.