Issues
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Cover image
Cover Image
Cover: The morphology of a Drosophila type II neural stem cell lineage, which includes both neurons and glia. The slice depth is color-coded from blue to red, anterior to posterior. The neuropil structures (grey) are revealed by antibody staining against Bruchpilot, a cytoskeletal protein in pre-synaptic active zones. See Research article by Ren et al. (dev160127)
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RESEARCH HIGHLIGHT
SPOTLIGHT
An interview with Elly Tanaka
Summary: Elly Tanaka discusses how she became interested in regeneration and why the axolotl is such a great model, as well as the importance of giving a voice to the next generation of researchers.
DEVELOPMENT AT A GLANCE
Wnt signaling in development and tissue homeostasis
Summary: An overview of Wnt-β-catenin signaling highlighting its key functions during development and adult tissue homeostasis.
MEETING REVIEW
A symphony of stem cells in Vienna – looking to the future
Summary: The first SY-Stem meeting in Vienna brought together emerging leaders in stem cell biology, who presented their wide-ranging high-quality research, laying the foundations for dynamic future collaborations.
STEM CELLS AND REGENERATION
Lineage-guided Notch-dependent gliogenesis by Drosophila multi-potent progenitors
Summary: Drosophila multi-potent progenitors produce brain region-specific glial populations, including astrocyte-like and ensheathing glia, with Notch signaling promoting the switch to glial fate and subsequent expansion.
Genetic screening and multipotency in rhesus monkey haploid neural progenitor cells
Summary: Monkey haploid neural progenitor cells are proliferative and multipotent, yielding a range of neural subtypes that can serve as powerful tools to identify neural toxicant targets via high-throughput genetic screening.
A regulatory pathway involving retinoic acid and calcineurin demarcates and maintains joint cells and osteoblasts in regenerating fin
Summary: Appropriate differentiation of pre-osteoblasts into joint cells or osteoblasts during fin regeneration is controlled in part by retinoic acid-dependent regulation of hoxa13a, evx1 and pthlha expression.
RESEARCH ARTICLES
Hobbit regulates intracellular trafficking to drive insulin-dependent growth during Drosophila development
Summary: Phenotypic analysis of hobbit mutants reveals that Hobbit is a novel and conserved regulator of body size in Drosophila that plays a specific role in secretory granule membrane protein trafficking.
Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation
Highlighted Article: A new ‘clock and scaled gradient’ model of zebrafish somite formation demonstrates that dynamic gradient scaling in the presomitic mesoderm plays a central role in progression and size control of somitogenesis.
Distinct regulation of Snail in two muscle lineages of the ascidian embryo achieves temporal coordination of muscle development
Summary: Constitutively active Raf facilitates direct activation of Snail by Zic-r.a, providing a gene circuit shortcut that allows temporal coordination of cellular developmental programs of distinct somatic lineages.
Transcriptional induction of cell wall remodelling genes is coupled to microtubule-driven growth isotropy at the shoot apex in Arabidopsis
Summary: In Arabidopsis, a regulatory module activated during organ outgrowth tightly links cytoskeleton organization to cell wall remodelling.
The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye
Summary: Analysis of temperature-sensitive mutants identifies a novel role for the lipid phosphatase Sac1 in regulating epithelial patterning and microtubule organization during early stages of Drosophila eye development.
The transcription factor SOX30 is a key regulator of mouse spermiogenesis
Summary: SOX30 plays a key role in round spermatid development and chromocenter formation, and regulates diverse families of protein-coding and lncRNA genes, including Sox30 itself.
PI(4,5)P2 forms dynamic cortical structures and directs actin distribution as well as polarity in Caenorhabditis elegans embryos
Highlighted Article: PI(4,5)P2 is distributed in dynamic cortical structures and regulates asymmetric division by controlling actin organization as well as cell polarity in the one-cell C. elegans embryo.
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.