Issues
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Cover image
Cover Image
Cover: A mammary epithelial organoid derived from one primary mouse basal epithelial cell embedded in reconstituted basement membrane. The basal markers alpha smooth muscle actin (red) and Slug (green), the luminal marker keratin 8 (yellow), and nuclei (blue; DAPI) are labelled. See Research article by Peuhu et al. on p. 4103.
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IN THIS ISSUE
REVIEWS
Fibroblast growth factors: key players in regeneration and tissue repair
Summary: This Review summarizes the roles of fibroblast growth factors in repair and regeneration of different tissues and organs and in different organisms, ranging from planarians to humans.
The evolution of cortical development: the synapsid-diapsid divergence
Summary: New technologies are emerging to allow studies of cortical development in diapsid (reptiles and birds) embryos that should address several key unresolved issues, including the fast evolution of the human cortex.
Developing a sense of touch
Summary: This Review presents current knowledge of the development of the sensory microdomains in mammalian skin and the mechanosensory neurons that innervate them.
STEM CELLS AND REGENERATION
Interorgan regulation of Drosophila intestinal stem cell proliferation by a hybrid organ boundary zone
Highlighted Article: Gene expression at the Drosophila midgut-hindgut boundary is a hybrid of both organs. Hybrid cells repress stem cell mitosis, but organ injury drives stem cell mitosis by interorgan STAT signaling.
Epithelial vimentin plays a functional role in mammary gland development
Summary: Loss of vimentin leads to altered gene expression and impedes the growth of basal mammary epithelium, which might be of importance in developing therapeutic strategies against breast cancer.
RESEARCH ARTICLES
The African Zika virus MR-766 is more virulent and causes more severe brain damage than current Asian lineage and dengue virus
Highlighted Article: African Zika virus MR-766 causes more cell death in NPCs and neurons in the developing brain, leading to more potent brain damage than Asian strain MEX1-44 and dengue virus.
Synaptic input as a directional cue for migrating interneuron precursors
Highlighted Article: Precursors of inhibitory interneurons receive an unprecedented early GABAergic and glutamatergic synaptic input while in transit through the cerebellar cortex that directs their mobility and directionality.
Regulation of mitosis-meiosis transition by the ubiquitin ligase β-TrCP in male germ cells
Summary: The transition of mouse male germ cells from mitosis to meiosis is regulated by β-TrCP-mediated degradation of DMRT1, a mechanism that arose after the evolutionary divergence of vertebrates from invertebrates.
Talin regulates integrin β1-dependent and -independent cell functions in ureteric bud development
Summary: Talin proteins regulate kidney collecting duct development through mechanisms that extend beyond those that require binding to the β1 integrin subunit NPxY motif in their cytoplasmic tail.
Graf regulates hematopoiesis through GEEC endocytosis of EGFR
Summary: During Drosophila hematopoiesis, Graf promotes downregulation of EGFR through GEEC-mediated endocytosis to restrain Spitz-dependent plasmatocyte proliferation. Defective EGFR downregulation may contribute to the development of a subset of myeloid malignancies.
Myc cooperates with β-catenin to drive gene expression in nephron progenitor cells
Summary: Characterization of a cell type-specific enhancer for the Wnt9b/β-catenin target gene Fam19a5 shows that Myc is necessary for activation of the β-catenin nephron progenitor cell renewal program.
PFKFB4 control of AKT signaling is essential for premigratory and migratory neural crest formation
Summary: Using constitutive or time-controlled depletion of PFKFB4 in Xenopus embryos, an essential role is identified for PFKFB4 and AKT signaling in formation of premigratory neural crest and its subsequent migration.
CORRECTION
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.