Issues

Summary: Development announces changes to the editorial team and invites community input in choosing a new Editor in Chief and in suggesting future areas for the journal to explore.

Summary: Jim Smith, recently knighted for services to medical research and science education, talks about his research career and his hopes for the future of biomedical science.

Summary: New, freely available illustrations of developing Xenopus laevis, drawn by Natalya Zahn, provide a resource for teaching and research, especially in the field of craniofacial biology.

Summary: This Meeting Review discusses recent progress in our understanding of neuronal programming, highlighting some of the common features of cell fate determination during development and directed reprogramming.

Summary: This Primer summarises our current understanding of the intriguing family of KRAB-ZFP transcriptional regulators and its contribution to the control, evolution and co-option of transposable elements.

Summary: Endothelium-derived soluble amyloid precursor protein negatively regulates the growth of neural stem cells to control neural stem cell number in the subventricular zone of the adult mouse brain.

Summary: Bone morphogenetic protein signaling is pivotal for muscle stem cell-dependent postnatal skeletal muscle growth and determination of the final adult muscle stem cell reservoir.

Highlighted article: A simple, transgene-free method is described for resetting human ESCs or iPSCs to a stable naïve status via transient histone deacetylase inhibition.

Highlighted article: A non-classical function of acetylcholinesterase in the polarization, rearrangement and adhesion of endoderm cells during Xenopus gut morphogenesis is identified.

Highlighted article: Calcium transients modulate the temporal dynamics of Dpp presentation in developmental BMP signaling, impacting the downstream transcriptional response and tissue morphogenesis.

Highlighted article: The genome-wide impact of Xist RNA lacking the A-repeat suggests a significant role for Xist in gene regulation beyond imprinted X inactivation.

Summary: Wnt16 signalling acts downstream of mechanical loading to shape developing joints through control of cell division and migration.

Summary: A new model is presented whereby multiple mesodermal tissues and signalling centres, rather than a single organizer, mediate the induction and patterning of chick sensory placodes.

Summary: Lrp4 can act as both inhibitor and activator of the Wnt/β-catenin pathway through interactions with Wise to determine tooth number and patterning in mouse.

Summary: The regulation of somatostatin (SST) and parvalbumin (PV) mouse cortical interneurons is mediated by Coup-TF1- and Coup-TF2-driven Sox6 expression, identifying a transcriptional pathway that controls SST-PV fate.

Summary: Genome editing in Xenopus oocytes employing homology-directed repair and DNA ligase inhibition effciently generates non-mosaic mutations with germline transmission.