Cover: A rendered image of a developing zebrafish embryo at mid-gastrulation stage. The embryo expresses membrane-GFP in differentiating surface cells under the keratin4 promoter (white) and histone-mCherry in all cells to label the nuclei (red). A dextran-alexa627 conjugate was injected in between the deep cells to label the interstitial fluid (blue). See Research article by Krens et al. on p. 1798.
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IN THIS ISSUE
Obituary: Tokindo S. Okada (1927-2017)
Summary: A retrospective on the life and work of the pioneering Japanese developmental biologist Tokindo Okada, whose research focussed on cell plasticity and transdifferentiation.
An interview with Eric Wieschaus
Summary: In our latest interview, Eric Wieschaus tells us about his Nobel Prize-winning fly screens, his interest in the cell biology of development and his love of painting.
The developmental biology of genetic Notch disorders
Summary: This Review discusses the developmental processes underlying Notch-related congenital disorders in humans, drawing on data from model organisms and genome-sequencing projects.
A small-molecule screen reveals that HSP90β promotes the conversion of induced pluripotent stem cell-derived endoderm to a hepatic fate and regulates HNF4A turnover
Highlighted Article: The heat shock protein HSP90β regulates the half-life of HNF4A and is necessary for efficient differentiation of hepatocytes from human iPSCs.
Development of organoids from mouse and human endometrium showing endometrial epithelium physiology and long-term expandability
Summary: Human endometrium organoids replicate the menstrual cycle in response to hormone treatment, while mouse endometrium organoid type is determined by variations in WNT.
STEM CELLS AND REGENERATION
A microRNA-mRNA expression network during oral siphon regeneration in Ciona
Summary: Network analysis during appendage regeneration in Ciona robusta predicts the importance of, the relationship between and the regulation of numerous gene functional categories during this process.
Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation
Highlighted Article: Segregation of the germ layer progenitors in the zebrafish gastrula is driven by directed cell migration, rather than differential tissue surface tension.
Excitatory neurons sculpt GABAergic neuronal connectivity in the C. elegans motor circuit
Highlighted Article: A non-cell-autonomous mechanism regulates inhibitory neuron synapse formation at the neuromuscular junction.
Blocked transcription through KvDMR1 results in absence of methylation and gene silencing resembling Beckwith-Wiedemann syndrome
Summary: Maternal inheritance of a mutation to block RNA elongation through KvDMR1 results in an absence of DNA methylation at KvDMR1, biallelic expression of Kcnq1ot1 and suppression of maternally expressed genes.
Reciprocal proteasome-mediated degradation of PIFs and HFR1 underlies photomorphogenic development in Arabidopsis
Summary: Reciprocal degradation of PIFs and HFR1 highlights a novel mechanism by which HLH factors regulate the abundance of bHLH factors to optimize photomorphogenesis in Arabidopsis.
Dose-dependent transduction of Hedgehog relies on phosphorylation-based feedback between the G-protein-coupled receptor Smoothened and the kinase Fused
Summary: A SMO/FU positive regulatory loop nested within a multikinase phosphorylation cascade regulates high level Hedgehog signaling in the Drosophila wing imaginal disc.
Sec71 functions as a GEF for the small GTPase Arf1 to govern dendrite pruning of Drosophila sensory neurons
Summary: The Arf1/Sec71-dependent secretory pathway governs Golgi integrity and dendrite pruning in Drosophila sensory neurons.
Novel role of Rac-Mid1 signaling in medial cerebellar development
Summary: Double knockout of Rac1 and Rac3 in cerebellar granule neurons impairs their tangential migration and final differentiation. Rac depleted cells exhibit decreased levels of Mid1 and impaired mTORC1 signaling.
Actomyosin-based tissue folding requires a multicellular myosin gradient
Summary: A combination of experimental work and theory reveals how gradients in transcription, signaling and resulting contractility shape tissue folding.
Dominant-negative Sox18 function inhibits dermal papilla maturation and differentiation in all murine hair types
Summary: The Sox18Op/+ mutation in mice, which mimics a hair loss condition in humans, leads to decreasing Wnt signal interactions with the hair follicle epidermis and abnormal hair follicle morphology.
Dynamics of growth zone patterning in the milkweed bug Oncopeltus fasciatus
Summary: A detailed analysis of posterior segment addition in an insect reveals that the growth zone is divided into two functional domains responsible for growth and differentiation.
Embryonic cholecystitis and defective gallbladder contraction in the Sox17-haploinsufficient mouse model of biliary atresia
Summary: Sox17 haploinsufficiency in the gallbladder induces ectopic cystic duct-like epithelia and defective smooth muscle formation by reduced Shh signals.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
The Forest of Biologists
We are excited to announce the launch of The Forest of Biologists, a new biodiversity initiative created with support from the Woodland Trust, aiming to counteract nature loss and safeguard some of the most critically endangered ecosystems for future generations. Click here to see our virtual forest: For every Research Article and Review/Commentary article that is published in Development a native tree is planted in a forest in the UK.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Pathway to Independence Programme - introducing our first PI Fellows
In December 2022, we announced a new programme aimed at supporting researchers as they transition from postdoc to Principal Investigator. We are delighted to announce that we have now selected our first cohort of PI fellows, meet them here.
Development Journal Meeting 2023
We are delighted to announce that our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ will be held from 17-20 September 2023 at Wotton House, Surrey, UK. Find out more and register here.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.