Issues
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Cover image
Cover Image
Cover: Stage 17 Drosophila melanogaster embryo (ventral view) showing Elav (green; neuronal nuclei), Spalt (yellow; subset of neuron and muscle nuclei), BP102 (red; CNS axons), Eve (magenta; subset of CNS nuclei, and ring of nuclei around anal pad), HRP (grey; neuronal cell bodies and axons) and DAPI (blue; nuclei) staining. The image was taken by Connie Rich (University of Cambridge, UK) at the 2014 Woods Hole MBL embryology course and was chosen by readers of the Node (http://thenode.biologists.com).
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IN THIS ISSUE
MEETING REVIEW
Heartbreak hotel: a convergence in cardiac regeneration
Summary: This Meeting Review summarises the key advances presented at the recent Company of Biologists workshop on Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation.
REVIEW
Plant regeneration: cellular origins and molecular mechanisms
Summary: This Review article summarises how plants control various types of regeneration and discusses how developmental and environmental constraints influence these regulatory mechanisms.
STEM CELLS AND REGENERATION
Trop2 marks transient gastric fetal epithelium and adult regenerating cells after epithelial damage
Summary: Trop2, a marker of gastric fetal glandular epithelium grown ex vivo, is re-expressed upon injury in adult regenerative cells together with a partial fetal-like genetic program.
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish
Summary: Regeneration of spinal motor neurons following mechanical lesion or genetic ablation occurs at the expense of oligodendrogenesis and is promoted by the innate immune system.
Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells
Highlighted article: Expression of cell surface protein ASGR1 can be used to isolate a subpopulation of more mature, homogenous hepatocyte-like cells derived during differentiation from pluripotent stem cells.
RESEARCH ARTICLES
A quantitative analysis of growth control in the Drosophila eye disc
Highlighted article: A quantitative analysis of growth dynamics of the Drosophila eye primordium reveals that the area growth rate declines in inverse proportion to the increasing total area.
Centrosomal protein CP110 controls maturation of the mother centriole during cilia biogenesis
Highlighted article: CP110 promotes the assembly of subdistal appendages and ciliary vesicle docking during cilia formation in vivo, thereby facilitating mammalian organogenesis.
Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
Highlighted article: Upregulation of replication-dependent core histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice.
Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth
Summary: Loss of LHX2 replicates a subset of the phenotypes seen in embryos with reduced NF-κB signaling, while exogenous TGFβ2 can rescue this effect in Lhx2 knockout skin explants.
An anterior signaling center patterns and sizes the anterior neuroectoderm of the sea urchin embryo
Summary: FoxQ2 activates an anterior signaling center that expresses the secreted Wnt modulators sFRP1/5 and Dkk3 – essential components of the Wnt network governing anterior-posterior neuroectoderm patterning.
RGMB and neogenin control cell differentiation in the developing olfactory epithelium
Summary: Ablation of RGMB expression, or of its receptor neogenin, leads to increased progenitor cell numbers and affects cell fate choice in the developing mouse olfactory epithelium.
Restricting calcium currents is required for correct fiber type specification in skeletal muscle
Summary: Developmental splicing of CaV1.1 restricts calcium currents in skeletal muscle, which are critical for activity-dependent regulation of fiber type specification and the prevention of mitochondrial damage.
Semaphorin 3A is a retrograde cell death signal in developing sympathetic neurons
Summary: A Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during their period of naturally occurring cell death.
Loss of Bmi1 causes anomalies in retinal development and degeneration of cone photoreceptors
Summary: Bmi1 is required to prevent postnatal degeneration of cone photoreceptors and bipolar neurons, while BMI1 inactivation in human embryonic stem cells impairs cone terminal differentiation.
aura (mid1ip1l) regulates the cytoskeleton at the zebrafish egg-to-embryo transition
Summary: The zebrafish maternal-effect gene aura encodes Mid1ip1l, which is involved in cytoskeletal rearrangements during the egg-to-embryo transition.
NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis
Summary: RNA polymerase II subunit NRPB3 interacts with stomatal bHLH transcription factors FAMA and ICE1, connecting the stomatal development pathway to the general transcription machinery.
Differential regulation of meristem size, morphology and organization by the ERECTA, CLAVATA and class III HD-ZIP pathways
Summary: Three pathways converge to regulate the balance between meristem size, morphology and organization in the Arabidopsis shoot apical meristem.
DRACULA2 is a dynamic nucleoporin with a role in regulating the shade avoidance syndrome in Arabidopsis
Summary: DRACULA2, an Arabidopsis nucleoporin with an SAS regulatory role, participates in nucleocytoplasmic transport and also appears to have a transport-independent role in controlling shade-induced gene expression.
CORRECTION
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
Development Journal Meeting 2022: From Stem Cells to Human Development
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Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
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Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells.
Propose a new Workshop
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Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
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Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.