IN THIS ISSUE
Summary: This Meeting Review summarises the key advances presented at the recent Company of Biologists workshop on Transdifferentiation and Tissue Plasticity in Cardiovascular Rejuvenation.
Summary: This Review article summarises how plants control various types of regeneration and discusses how developmental and environmental constraints influence these regulatory mechanisms.
STEM CELLS AND REGENERATION
Summary: Trop2, a marker of gastric fetal glandular epithelium grown ex vivo, is re-expressed upon injury in adult regenerative cells together with a partial fetal-like genetic program.
Spinal motor neurons are regenerated after mechanical lesion and genetic ablation in larval zebrafish
Summary: Regeneration of spinal motor neurons following mechanical lesion or genetic ablation occurs at the expense of oligodendrogenesis and is promoted by the innate immune system.
Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells
Highlighted article: Expression of cell surface protein ASGR1 can be used to isolate a subpopulation of more mature, homogenous hepatocyte-like cells derived during differentiation from pluripotent stem cells.
Highlighted article: A quantitative analysis of growth dynamics of the Drosophila eye primordium reveals that the area growth rate declines in inverse proportion to the increasing total area.
Highlighted article: CP110 promotes the assembly of subdistal appendages and ciliary vesicle docking during cilia formation in vivo, thereby facilitating mammalian organogenesis.
Retinoid signaling controls spermatogonial differentiation by regulating expression of replication-dependent core histone genes
Highlighted article: Upregulation of replication-dependent core histone genes by retinoic acid signaling contributes to spermatogonial differentiation in mice.
Summary: Loss of LHX2 replicates a subset of the phenotypes seen in embryos with reduced NF-κB signaling, while exogenous TGFβ2 can rescue this effect in Lhx2 knockout skin explants.
Summary: FoxQ2 activates an anterior signaling center that expresses the secreted Wnt modulators sFRP1/5 and Dkk3 – essential components of the Wnt network governing anterior-posterior neuroectoderm patterning.
Summary: Ablation of RGMB expression, or of its receptor neogenin, leads to increased progenitor cell numbers and affects cell fate choice in the developing mouse olfactory epithelium.
Summary: Developmental splicing of CaV1.1 restricts calcium currents in skeletal muscle, which are critical for activity-dependent regulation of fiber type specification and the prevention of mitochondrial damage.
Summary: A Sema3A-initiated apoptotic signaling complex regulates the apoptosis of sympathetic neurons during their period of naturally occurring cell death.
Summary: Bmi1 is required to prevent postnatal degeneration of cone photoreceptors and bipolar neurons, while BMI1 inactivation in human embryonic stem cells impairs cone terminal differentiation.
Summary: The zebrafish maternal-effect gene aura encodes Mid1ip1l, which is involved in cytoskeletal rearrangements during the egg-to-embryo transition.
NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis
Summary: RNA polymerase II subunit NRPB3 interacts with stomatal bHLH transcription factors FAMA and ICE1, connecting the stomatal development pathway to the general transcription machinery.
Differential regulation of meristem size, morphology and organization by the ERECTA, CLAVATA and class III HD-ZIP pathways
Summary: Three pathways converge to regulate the balance between meristem size, morphology and organization in the Arabidopsis shoot apical meristem.
DRACULA2 is a dynamic nucleoporin with a role in regulating the shade avoidance syndrome in Arabidopsis
Summary: DRACULA2, an Arabidopsis nucleoporin with an SAS regulatory role, participates in nucleocytoplasmic transport and also appears to have a transport-independent role in controlling shade-induced gene expression.