Issues
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Cover image
Cover Image
Cover: Stage 19 short-tailed fruit bat (Carollia perspicillata). On the left side is an image of the fixed embryo before staining; the right side shows the embryo after Alcian Blue staining for cartilage. This image, taken by Idoia Quintana-Urzainqui, Paola Bertucci, Peter Warth and Chi-Kuo Hu at the 2014 Woods Hole MBL Embryology course, was chosen by readers of the Node (http://thenode.biologists.com).
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IN THIS ISSUE
REVIEWS
Building and re-building the heart by cardiomyocyte proliferation
Summary: This Review article discusses the cellular and molecular mechanisms that control cardiomyocyte proliferation, during both heart development and regeneration across various species.
A comparative view of regenerative neurogenesis in vertebrates
Summary: This Review article provides a comparative view of neuronal repair across vertebrate species, with a particular focus on the molecular pathways that enable repair in some, but not all animals.
STEM CELLS AND REGENERATION
Chinmo is sufficient to induce male fate in somatic cells of the adult Drosophila ovary
Highlighted article: Manipulating expression of the transcription factor Chinmo in Drosophila gonads shows that sexual identity can be reprogrammed, and must be actively maintained throughout life.
BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors
Summary: In the mouse airway epithelium, regeneration after injury involves transient downregulation of BMP signaling to promote proliferation, followed by cell shedding to restore cell density.
RESEARCH REPORTS
MEF2C regulates outflow tract alignment and transcriptional control of Tdgf1
Summary: In the developing mouse anterior second heart field, the transcription factor MEF2C directly controls expression of the Nodal co-receptor Cripto to regulate outflow tract alignment.
GATA4 and GATA6 regulate pancreatic endoderm identity through inhibition of hedgehog signaling
Summary: Gata4 and Gata6 regulate mouse foregut endoderm patterning via control of hedgehog signaling. In their absence, the pancreatic anlage is respecified to intestinal and stomach fates.
RESEARCH ARTICLES
Tpbpa-Cre-mediated deletion of TFAP2C leads to deregulation of Cdkn1a, Akt1 and the ERK pathway, causing placental growth arrest
Highlighted article: In trophoblast progenitor cells, the transcription factor TFAP2C regulates proliferation and differentiation. Tfap2c mutant mice provide a model of intrauterine growth retardation.
Makorin ortholog LEP-2 regulates LIN-28 stability to promote the juvenile-to-adult transition in Caenorhabditis elegans
Highlighted article: The C. elegans Makorin homolog lep-2 is a heterochronic gene required for the proper timing of the juvenile-to-adult transition. It acts in the LIN-28/let-7 pathway.
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation
Highlighted article: Cardiac-specific depletion of the H3K4 methyltransferase KMT2D causes dysregulation of genes associated with cell cycle regulation, ion homeostasis and hypoxia signaling.
Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion
Summary: A radical/lunatic fringe chimeric allele predicted to affect protein secretion disrupts segmentation clock function and somite patterning with context-dependent effects.
The Lhx9-integrin pathway is essential for positioning of the proepicardial organ
Summary: In Xenopus, Lhx9, a LIM homeodomain protein, acts upstream of integrin-paxillin signaling to control positioning and migration of proepicardial cells, and subsequent epicardium formation.
Selection of cell fate in the organ of Corti involves the integration of Hes/Hey signaling at the Atoh1 promoter
Summary: Defining and patterning cell fate in the mouse cochlea depends on integration of developmental signals at highly conserved regions of the Atoh1 promoter.
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1
Summary: In C. elegans, depletion of the histone demethylase rbr-2 leads to axon guidance defects that can be attributed to NURF-mediated ectopic expression of the actin regulator wsp-1.
A gradient of maternal Bicaudal-C controls vertebrate embryogenesis via translational repression of mRNAs encoding cell fate regulators
Summary: Maternally deposited Bicaudal-C, an RNA-binding protein, controls Xenopus early embryonic patterning by repressing translation of cell fate regulators, including Wnt11b.
Endothelial cell specification in the somite is compromised in Pax3-positive progenitors of Foxc1/2 conditional mutants, with loss of forelimb myogenesis
Summary: The endothelial versus myogenic fate choice in the somite requires Foxc1/2. In conditional Foxc1/2 mutants, endothelial cell loss compromises migration of myogenic cells to the limb.
The late and dual origin of cerebrospinal fluid-contacting neurons in the mouse spinal cord
Summary: Neurogenesis at advanced embryonic stages, during the gliogenic phase of spinal cord development, generates neurons of the central canal.
Rab8 directs furrow ingression and membrane addition during epithelial formation in Drosophila melanogaster
Summary: During Drosophila cellularization, the GTPase Rab8 guides the targeting of cytoplasmic membrane stores to the cell surface through interactions with the exocyst complex.
CORRECTION
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
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Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
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Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.