Issues
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Cover image
Cover Image
Cover:Spectral karyotyping of a metaphase cerebellar granule neuron progenitor from a P3 mouse with conditional deletion of Atr demonstrates complex chromosomal rearrangements, including fusions and translocations, revealing that ATR plays a crucial role in maintaining genomic integrity during brain development. Each chromosome is labelled in a different colour. See Research article by Lang et al. on p. 4038.
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IN THIS ISSUE
SPOTLIGHT
An interview with Paola Arlotta
Summary: Neurodevelopmental biologist Paola Arlotta discusses her research and career, as well as her recent efforts to support women in science.
MEETING REVIEW
Rebuilding a broken heart: lessons from developmental and regenerative biology
Summary: This Meeting Review summarises the findings presented at the 2016 Weinstein Cardiovascular Development Conference, highlighting the range of research currently being applied to study human cardiac diseases.
REVIEWS
Post-transcriptional modifications in development and stem cells
Summary: Post-transcriptional modifications regulate stem cell functions in development and adult tissues by co-ordinating the availability and sequence of transcripts that maintain the cell type-specific proteome.
The functions of long noncoding RNAs in development and stem cells
Summary: This Review discusses the known biological functions of mammalian lncRNAs and highlights emerging paradigms of their modes of action.
STEM CELLS AND REGENERATION
Emergence of dorsal-ventral polarity in ESC-derived retinal tissue
Highlighted article: Intrinsic mechanisms involving the spatiotemporal regulation of canonical Wnt and BMP signals play a role in setting up DV polarity in mouse ESC-derived optic cups.
Notch signaling promotes nephrogenesis by downregulating Six2
Summary: Notch is necessary and sufficient for downregulation of Six2 during nephrogenesis, while nephron progenitors that lack Notch signaling fail to form all segments of the nephron, not just proximal tubules.
Somatic stem cell differentiation is regulated by PI3K/Tor signaling in response to local cues
Summary: Proper differentiation of somatic cyst stem cells as they move away from their niche requires an increase in PI3K/Tor signaling, downstream of Insulin receptor activation.
RESEARCH REPORT
A link between planar polarity and staircase-like bundle architecture in hair cells
Summary: In the mouse cochlea, LGN and Gai guide planar polarity in hair cells and are essential for stereocilia elongation, the staircase pattern of the hair bundle and hearing.
RESEARCH ARTICLES
Deposition of collagen type I onto skeletal endothelium reveals a new role for blood vessels in regulating bone morphology
Highlighted article: Collagen I is deposited by osteoblasts onto endothelial cells within bone and serves as a template for mineralisation, with ossification thus spatially and temporally following vascular patterning.
Members of the Rusc protein family interact with Sufu and inhibit vertebrate Hedgehog signaling
Highlighted article: Rusc proteins are identified as novel components of the vertebrate Hedgehog pathway that bind Sufu and prevent the signaling-induced dissociation of Sufu and Gli.
Functional roles of MMP14 and MMP15 in early postnatal mammary gland development
Highlighted article: Global deletion of MMP14 or MMP15 has no significant effect on mammary gland branching but uncovers unexpected and differential roles for these MMPs in adipose development in mice.
Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
Highlighted article: Tissue-clearing and imaging of intact human embryos reveals previously unprecedented GnRH neuron target sites and routes of migration into the brain.
Cytokinin acts through the auxin influx carrier AUX1 to regulate cell elongation in the root
Highlighted article: A model for how cytokinin inhibits Arabidopsis root cell elongation, working in concert with the hormones auxin and ethylene, is put forward.
Control of lens development by Lhx2-regulated neuroretinal FGFs
Summary: The LIM homeodomain transcription factor Lhx2 regulates FGF3, FGF9 and FGF15 and is essential for lens cell proliferation, survival and differentiation in mice.
Notch-Wnt-Bmp crosstalk regulates radial patterning in the mouse cochlea in a spatiotemporal manner
Summary: Forced activation of Wnt signaling in the sensory domain of the developing cochlea impacts radial patterning and downstream gene expression in a spatiotemporal manner.
Tril targets Smad7 for degradation to allow hematopoietic specification in Xenopus embryos
Summary: Tril is a Gata2 target gene that triggers degradation of Smad7 protein during gastrulation, allowing for robust transduction of Bmp signals to enable the commitment of mesoderm to a blood fate.
Tissue-specific roles for sonic hedgehog signaling in establishing thymus and parathyroid organ fate
Summary: SHH signaling within both the neural crest and endoderm influences thymus and parathyroid cell fate establishment and subsequent organogenesis.
ATR maintains chromosomal integrity during postnatal cerebellar neurogenesis and is required for medulloblastoma formation
Summary: The serine/threonine kinase ATR prevents chromosome fragmentation during postnatal cerebellar neurogenesis in mice, suggesting that ATR dependence may be exploited for medulloblastoma therapy.
Boronic acid treatment phenocopies monopteros by affecting PIN1 membrane stability and polar auxin transport in Arabidopsis thaliana embryos
Summary: The boron competitor phenylboronic acid differentially affects membrane proteins and interrupts the auxin signalling pathway, leading to perturbed embryonic root development in Arabidopsis.
Control of root cap maturation and cell detachment by BEARSKIN transcription factors in Arabidopsis
Summary: Arabidopsis NAC transcription factors BRN1 and BRN2 are specifically expressed in the outer root cap layer and activate genes associated with its cellular functions.
TECHNIQUES AND RESOURCES
Monitoring cell-cell contacts in vivo in transgenic animals
Summary: A synthetic genetic system is used to monitor cell-cell contacts in animals, to genetically manipulate interacting cells, and to investigate the connectivity of neurons in brain circuits.
Reversible optogenetic control of kinase activity during differentiation and embryonic development
Summary: Light is used to modulate the timing of mitogen-activated protein kinase activity during PC12 cell differentiation and distinct developmental stages of Xenopus embryos.
ARTICLES OF INTEREST IN OUR OTHER JOURNALS
From Journal of Cell Science
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.