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IN THIS ISSUE

SPOTLIGHT

Summary: This Spotlight revisits a landmark paper in developmental biology, published 25 years ago, that reported the sex reversal of an XX mouse carrying an Sry transgene.

CORRESPONDENCE

DEVELOPMENT AT A GLANCE

Summary: This Development at a Glance article summarises mammalian pluripotency both in vivo and in vitro, and highlights recent and future applications of PSCs for basic and translational research.

MEETING REVIEW

Summary: This Meeting Review summarises the exciting work that was presented at the Fusion meeting on Adult Neurogenesis, which was held in March 2016 in Cancun, Mexico.

STEM CELLS AND REGENERATION

Summary: SUMOylation promotes proliferation of cyst stem cells in the Drosophila testis. The transcription factor Ci is SUMOylated, enhancing Hedgehog pathway activity in these cells.

Highlighted article: In the mouse mammary gland, Blimp1 marks a rare progenitor population, and is required for cell proliferation and polarity as well as efficient milk production.

Summary: In the squamous epithelium of the mouse skin, the transcription factors YAP and TAZ are regulated by integrin-Src signalling, and are required for proliferation of skin stem/progenitor cells.

Summary: Lineage tracing of cardiomyocytes in the zebrafish heart reveal their proliferation dynamics and fate decisions, and distinguish atrial and ventricular morphogenesis at the cellular level.

Summary: The response of planarian neoblasts to DNA damage differs according to their location, with both cell autonomous and non-autonomous mechanisms contributing to these regional differences.

Summary: In the Drosophila intestine, Tankyrase is important for Wingless signaling activation in enterocytes, thus non-autonomously regulating intestinal stem cell proliferation.

RESEARCH ARTICLES

Highlighted article: In the mouse spinal cord, single-stranded DNA binding proteins are key cofactors in LIM-containing complexes, recruiting histone-modifying enzymes to promote transcription.

Highlighted article: Elongation of the vertebrate body axis by posterior volumetric growth is linked to increased energy supply and is absent from the externally developing zebrafish embryo.

Highlighted article: Naturally occurring hypoxia and HIF pathway activation at an early stage of chick development is required to produce sufficient cranial neural crest cells through EMT.

Highlighted article: Migrating interneurons reach their targets not only via the well-established caudal route, but also via rostrally directed streams that require the COUP-TF nuclear receptors.

Summary: Wnt signalling and the Six3/6 transcription factors play conserved functions in primary axis patterning in bilateria, controlling aboral/anterior identity in Nematostella.

Summary: In mice, JNK and WNT4 antagonistically regulate E-cadherin expression and oocyte-oocyte adhesion during germline cyst breakdown and primordial follicle formation.

Summary:Setdb1-deficient pro-B cells display derepression of endogenous murine leukemia virus (MLV) elements. This induces the unfolded protein response and apoptosis, blocking B cell development.

Summary: Medaka Pax1 plays a key role in generating the primary pattern for segmentation in the pharyngeal endoderm by regulating the expression of Tbx1 and Fgf3.

Summary: Conditional ablation of Fgfr1 and Fgfr2 in the osteoblast lineage in mouse reveals a feed-forward loop controlling FGFR3 signaling in growth plate chondrocytes.

TECHNIQUES AND RESOURCES

Summary: A new transgenic mouse line allows sebocyte-specific gene targeting and investigation of the importance of sebaceous lipids in the skin and eyelids.

CORRECTION

ARTICLES OF INTEREST IN OUR OTHER JOURNALS

From Journal of Cell Science
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