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Summary: This Review discusses how intrinsic regulatory mechanisms as well as extrinsic factors, such as mechanical force, regulate the extracellular matrix to control tendon development and maturation.


Highlighted article: Quantitative measurements and mathematical modeling reveal the integration of transcription factor activity and extracellular signaling during fate decisions in ESCs.

Highlighted article: Restoration of brain:body proportion after injury in planarians involves spatial Wnt/Notum feedback inhibition to control brain cell differentiation and target organ size.

Highlighted article: Negative feedback regulation by differentiated progeny and insulin/IGF-1 signalling provides a tissue-specific mechanism for age-related decline in germline stem cell proliferation.

Summary: A COP9-Hh signaling axis, which partly represses BMP signaling, is required in the Drosophila ovary to control germline stem cell lineage specification within the differentiation niche.

Highlighted article: Two new endoderm-specific cell surface antibodies, HDE1 and HDE2, identify and isolate liver-fated endoderm subpopulations with high specificity in differentiating human embryonic stem cells.


Highlighted article: A specialized pool of angioblasts is the origin of the zebrafish subintestinal plexus, a structure that gives rise to the organ-specific vessels of the gut, liver and pancreas.

Summary: The Drosophila Eclosion hormone null mutant phenotype reveals an essential role for Eclosion hormone in the CNS, where it is required for Ecdysis triggering hormone to activate ecdysis.

Summary: S phase-coupled destruction of the Drosophila CDK inhibitor Dacapo mediates oscillations of Dap protein accumulation and may help to regulate endocycle frequency and polyploidization during development.

Summary: The CAG promoter drives a new Xist allele, XistCAG, upregulation of which in preimplantation embryos temporally differs depending on its parental origin.

Summary: Conditional genetics in the developing mouse embryo reveals discrete spatiotemporal functions of β-catenin in taste papilla morphogenesis and taste bud differentiation.

Summary: Absence of Tag1 in mice results in fewer mitral cells in the olfactory bulb, which is associated with diminished odor discrimination ability and social long-term memory formation.

Summary: Single-cell fate mapping and 3D cell tracking in zebrafish reveal a Tbx5a-dependent cell convergence pattern within the fin-field lateral plate mesoderm during early fin bud initiation.

Summary: Transcriptional targets of SOX9 in developing tissues mapped by ChIP-Seq reveal that SOX9 mediates cell proliferation as well as differentiation during embryonic heart valve formation.

Summary: Deletion of tropomodulin 4 induces compensatory upregulation of tropomodulin 1 to preserve thin filament lengths in mouse skeletal muscle. Knockdown of tropomodulin 1 results in increased thin filament lengths.

Summary: Neuropilin 1 and β8 integrin cooperatively promote cerebral angiogenesis by mediating adhesion and signaling events between neuroepithelial cells and vascular endothelial cells in the mouse brain.


Summary: The auxin-inducible degradation (AID) system is adapted to C. elegans to enable conditional depletion of degron-tagged protein targets in as little as twenty minutes.

Summary: New fluorescent indicator alleles utilize Cre, Flp and Dre recombinases to label previously inaccessible cell populations. The complete architecture of two cell populations can be visualized in the same mouse.


From Journal of Cell Science
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