IN THIS ISSUE
Plant germline formation: common concepts and developmental flexibility in sexual and asexual reproduction
Summary: New insights into the genetic basis and molecular mechanisms underlying plant germline development in sexual and asexual species are discussed.
Summary: The current status of the neural crest gene regulatory network is reviewed, emphasizing the connections between transcription factors, signalling molecules and epigenetic modifiers.
STEM CELLS AND REGENERATION
Highlighted article: In the adult mouse lung, Notch3 identifies a population of parabasal cells and regulates the balance between basal and parabasal progenitor pools.
Higlighted article: In the Drosophila testis, profilin and septate junction components are required for encapsulation and isolation of the germline by a somatic permeability barrier.
The carboxy-terminus of p63 links cell cycle control and the proliferative potential of epidermal progenitor cells
Summary: In the mouse skin, the C-terminus of p63 regulates the expression of p21Waf1/Cip, a cylin independent kinase inhibitor, to maintain stem cell proliferation.
Proteasome regulation of the chromodomain protein MRG-1 controls the balance between proliferative fate and differentiation in the C. elegans germ line
Summary: The C. elegans chromodomain protein MRG-1 promotes proliferation in the germline, and its activity is regulated by the putative E3 ubiquitin ligase RFP-1 and proteasomal degradation.
Postnatal subventricular zone progenitors switch their fate to generate neurons with distinct synaptic input patterns
Summary: Heterochronic grafting experiments using postnatal or adult SVZ progenitors reveal key differences in the connective properties of the neurons generated.
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
Summary: Although VEGF165 was thought to be the sole VEGF isoform acting through neuropilin 1 (NRP1), VEGF189 also binds to and signals through NRP1 in several types of developing mouse neurons.
Canonical Wnt signalling regulates epithelial patterning by modulating levels of laminins in zebrafish appendages
Highlighted article: In the zebrafish fin, a Wnt gradient dictates the expression of laminin α5, which signals via integrin α3 to control epithelial cell morphology.
Highlighted article: Enteric neural crest cells act as a new mediator in the mesenchymal-epithelial interactions that control proper patterning and differentiation in the chick stomach.
Cyclic AMP in oocytes controls meiotic prophase I and primordial folliculogenesis in the perinatal mouse ovary
Summary: In mouse ovaries, meiotic progression and primordial follicle formation are regulated by cAMP levels in oocytes through the disassembly and degradation of synaptonemal complex protein 1.
UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome
Summary: Sertoli cell-specific disruption of upf2, a component of the nonsense-mediated decay machinery, leads to global defects in transcription, Sertoli and germ cell depletion, and sterility.
Microtubule-dependent apical restriction of recycling endosomes sustains adherens junctions during morphogenesis of the Drosophila tracheal system
Summary: In the tracheal system of the Drosophila embryo, microtubules mediate the shuttling of E-cadherin and Par3 to the apical compartment via dynein powered recycling endosomes.
Summary: Disrupting the calcium sensor calmodulin 1 in mouse precerebellar neurons impairs both radial and tangential migration of these cells, while Calm2 or 3 depletion has no effect.
Summary: Inactivation of zbtb20 in developing mouse chondrocytes results in delayed endochondral ossification, due to increased Sox9 and reduced Vegfa expression in the mutant tissue.
TECHNIQUES AND RESOURCES
Investigating CNS synaptogenesis at single-synapse resolution by combining reverse genetics with correlative light and electron microscopy
Summary: Genetic tools, and 3D correlative light and electron microscopy allow the dissection of the mechanisms governing synaptogenesis at single-cell resolution in the Drosophila CNS.