Cover: Wild-type mouse P6 retinal blood vessels visualised by confocal microscopy following antibody staining for collagen IV (blue), isolectin B4 (red) and R26R-YFP (green) to report Cre activity during conditional endothelial Cdc42 deletion. Cdc42 is a central regulator of the cellular machinery in endothelial cells that is essential during blood vessel development. See Research article by Barry et al. on p. 3058.
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IN THIS ISSUE
An interview with Didier Stainier
Summary: We spoke to Didier Stainier, Director of the Max Planck Institute for Heart and Lung Research, about his career working with zebrafish and his recent move from the USA to Germany.
Neuromesodermal progenitors and the making of the spinal cord
Summary: This Hypothesis considers the growing evidence for a dual origin of the central nervous system: as well as the neuroectoderm lineage, neuromesodermal progenitors contribute to the spinal cord.
Trithorax and Polycomb group-dependent regulation: a tale of opposing activities
Summary: This Review discusses the complex and dynamic interplay between the Polycomb and Trithorax group proteins, known for maintaining epigenetically stable expression states.
STEM CELLS AND REGENERATION
Retinoic acid signaling spatially restricts osteoblasts and controls ray-interray organization during zebrafish fin regeneration
Highlighted article: A Cyp26a1-expressing niche in the basal epidermal layer of the zebrafish fin controls osteoblast localisation during regeneration - thus defining ray patterning.
Osteoblast de- and redifferentiation are controlled by a dynamic response to retinoic acid during zebrafish fin regeneration
Highlighted article: Multiple steps of ray regeneration in the zebrafish fin require dynamic modulation of retinoic acid signalling, regulated by the retinoic acid-degrading enzyme Cyp26b1.
Brain oxygen tension controls the expansion of outer subventricular zone-like basal progenitors in the developing mouse brain
Highlighted article: In the developing mouse brain, hypoxia impairs proliferation and causes apoptosis, while hyperoxia induces the expansion of a normally rare population of neural progenitors.
Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus
Summary: Modulating histone H3K27 methylation state during leg regeneration in cricket leads to defects in proximodistal patterning of the regenerating limb.
Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation
Summary: During early zebrafish heart development, three distinct phases of endoderm convergence and myocardial cell migration can be identified, all of which rely on S1pr2/Gα13 signalling.
Root developmental programs shape the Medicago truncatula nodule meristem
Summary: In the legume Medicago, the PLETHORA genes are expressed in the nodule meristem and regulate nodule formation, indicating the recruitment of root developmental programs by Rhizobium.
Single-cell analysis of endothelial morphogenesis in vivo
Highlighted article: Following the behaviour of single cells during vessel formation at high spatio-temporal resolution provides insights into endothelial cell migration and lumen formation.
Hippo signaling is required for Notch-dependent smooth muscle differentiation of neural crest
Highlighted article: Direct interaction between the Hippo effector Yap and the Notch intracellular domain regulates Notch target gene expression during vascular smooth muscle differentiation from neural crest.
Key mediators of somatic ATR signaling localize to unpaired chromosomes in spermatocytes
Summary: Meiotic chromosomal regions that fail to synapse elicit meiotic silencing of unsynapsed chromatin (MSUC), which shows similarities to the DNA damage response to replication stress in somatic cells.
Epithelial inactivation of Yy1 abrogates lung branching morphogenesis
Summary: Genetic ablation of the transcription factor YY1 in mouse lung epithelium disrupts lung branching and leads to cyst formation, a phenotype reminiscent of pleuropulmonary blastoma.
Kinesin-1 interacts with Bucky ball to form germ cells and is required to pattern the zebrafish body axis
Summary: Bucky ball is essential for germ plasm assembly in zebrafish. It binds Kinesin-1, which promotes microtubule reorganisation after egg activation and is required for Bucky ball activity.
Meis1 coordinates a network of genes implicated in eye development and microphthalmia
Summary: The transcription factor Meis1 controls expression of a set of eye territory-specific transcription factors. Meis1 haploinsufficiency causes micropthalmia and visual impairment in adult mice.
Yap and Taz regulate retinal pigment epithelial cell fate
Summary: In zebrafish, the transcriptional regulators Yap/Taz and Tead are necessary and sufficient for optic vesicle progenitors to adopt retinal pigmented epithelium identity.
Protein phosphatase 2A promotes the transition to G0 during terminal differentiation in Drosophila
Summary: Protein phosphatase 2A controls cell cycle progression in the developing Drosophila eye and wing - inhibiting Cdk2/Cyclin E to induce the quiescent state.
Pasiflora proteins are novel core components of the septate junction
Summary: Two tetraspan membrane proteins, Pasiflora1 and 2, are essential components of the Drosophila septate junction required for epithelial and blood-brain barrier integrity.
Cdc42 is required for cytoskeletal support of endothelial cell adhesion during blood vessel formation in mice
Summary: Cdc42 and its effectors Pak2/4 and N-WASP are required for organisation of the actin cytoskeleton during blood vessel development, both in filopodia and nascent cell-cell junctions.
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
A local VE-cadherin and Trio-based signaling complex stabilizes endothelial junctions through Rac1
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Development presents… Outstanding Paper Prize Finalists
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Development Journal Meeting 2023
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Keeping up with the Node
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