Cover: The complexity of cell movements during quail embryogenesis is illustrated by this pseudocoloured composite image of 30 superimposed stills from a time-lapse movie of heart and dorsal aortae formation in a Tg(PGK1:H2B-chFP; TIE1:H2B-eYFP) double transgenic quail embryo. Endothelial cell nuclei are yellow and all cell nuclei are magenta. See Research article by Huss et al. on p. 2850.
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IN THIS ISSUE
An interview with Caroline Dean
Summary: We talked to Caroline Dean - a plant biologist based at the John Innes Centre in Norwich, UK - about her career, her FEBS EMBO Women in Science Award, and her thoughts on the plant field.
The embryo reunited with its membranes in Göttingen
Summary: This Meeting Review summarises the work and advances presented at the recent EMBO Workshop on Embryonic-Extraembryonic Interfaces
Primordial germ cells: the first cell lineage or the last cells standing?
Summary: In this Hypothesis article, Johnson and Alberio propose that the determinative mechanisms for PGC specification in most model systems evolved to promote speciation and evolvability, not to maintain the germ line.
STEM CELLS AND REGENERATION
Scalloped and Yorkie are required for cell cycle re-entry of quiescent cells after tissue damage
Highlighted article: The Hippo pathway transcriptional effectors Scalloped and Yorkie are required to drive quiescent cells into the cell cycle in response to tissue damage in the developing Drosophila eye.
Control of tissue growth by Yap relies on cell density and F-actin in zebrafish fin regeneration
Highlighted article: Yap, a Hippo pathway effector, is required to regulate cell proliferation and is regulated by changes in cell density and cell morphology to control fin regeneration.
The thyroid hormone nuclear receptor TRα1 controls the Notch signaling pathway and cell fate in murine intestine
Summary: Thyroid hormones and the TRα1 nuclear receptor regulate Notch signaling and hence the balance between cell proliferation and cell differentiation in intestinal cells.
Endothelin signaling activates Mef2c expression in the neural crest through a MEF2C-dependent positive-feedback transcriptional pathway
Summary: The MADS box transcription factor MEF2C is identified as an immediate downstream target of endothelin and is part of a positive-feedback mechanism for endothelin induction in the neural crest.
Fat1 interacts with Fat4 to regulate neural tube closure, neural progenitor proliferation and apical constriction during mouse brain development
Highlighted article: Fat1-Fat4 dimer formation is proposed to bring together diverse proteins at apical junctions to regulate both apical constriction and progenitor cell divisions in the neural tube.
Otx2 is a target of N-myc and acts as a suppressor of sensory development in the mammalian cochlea
Summary: A microarray-based screen identifies Otx2 as a crucial target of N-myc, and further studies show that Otx2 is essential for spatial restriction of the sensory domain in the mammalian cochlea.
Anteroposterior patterning of Drosophila ocelli requires an anti-repressor mechanism within the hh pathway mediated by the Six3 gene Optix
Summary: The development of Drosophila ocelli requires dynamic changes in Hh signaling domains that are regulated by the Hh signaling target engrailed and the Drosophila Six3/6 homolog Optix.
Neurog1 can partially substitute for Atoh1 function in hair cell differentiation and maintenance during organ of Corti development
Summary: The transcription factor Neurog1 may in part mimic Atoh1 activity, which is essential for hair fate determination, but cannot fully regulate stereocilia maturation and inner ear patterning.
Changes in cis-regulatory elements of a key floral regulator are associated with divergence of inflorescence architectures
Summary: Alterations of floral meristem identity gene expression patterns during evolution involve changes in both cis-regulatory elements and upstream trans-acting factors.
TECHNIQUES AND RESOURCES
Efficient CRISPR-mediated gene targeting and transgene replacement in the beetle Tribolium castaneum
Summary: CRISPR-based technology can mediate efficient gene targeting and transgene replacement in the beetle Tribolium, which is emerging as a powerful insect model organism.
Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity
Highlighted article: The heterogeneous and fluctuating expression of a Nanog reporter is coupled to various cell- and population-based features in mouse embryonic stem cells.
A transgenic quail model that enables dynamic imaging of amniote embryogenesis
Summary: A novel transgenic quail that ubiquitously expresses nuclear localized CherryFP provides insights into the cellular and morphogenetic events of amniote embryogenesis.
Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Disease Models & Mechanisms
Enolase 1 (ENO1) and protein disulfide-isomerase associated 3 (PDIA3) regulate Wnt/β-catenin-driven trans-differentiation of murine alveolar epithelial cells
Deducing the stage of origin of Wilms' tumours from a developmental series of Wt1-mutant mice
The Forest of Biologists
The Forest of Biologists is a biodiversity initiative created by The Company of Biologists, with support from the Woodland Trust. For every Research and Review article published in Development a native tree is planted in a UK forest. In addition to this we are protecting and restoring ancient woodland and are dedicating these trees to our peer reviewers. Visit our virtual forest to learn more.
Propose a new Workshop for 2025
Do you have an idea for a Workshop? We are now accepting proposals for our 2025 Biologists Workshops programme. As the scientific organiser, your involvement will be focused on the science. We'll take care of all the logistics. In 2025 we'll continue our efforts to diversify our Workshop programme and will be reserving one of our Workshops for an application from a Global South (GS) country to host an event overseas.
Development presents… Outstanding Paper Prize Finalists
On Wednesday 19 April, Development hosted a webinar celebrating the finalists for Development’s Inaugural Outstanding Paper Prize. The talks and Q&As were hosted by our Deputy Editor, Steve Wilson (UCL).
Development Journal Meeting 2023
The Abstract deadline for our 2023 Journal Meeting ‘Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology’ is 23 June 2023. Find out more and apply here
Keeping up with the Node
Thirteen years on from its launch, the Node continues to be a place to share research stories, opinions, job adverts and event listings. Development have published a recent Editorial reviewing some of our most popular features, as well as introducing some new initiatives.