Issues
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Cover image
Cover Image
Cover: Drosophila third instar larval eye disc attached to a brain lobe. The transcription factor Cut (red) is expressed in many cells, including the wrapping glia (GFP, green), and forms part of a transcriptional network controlling glial development in the Drosophila visual system. Neuronal membranes are in blue. See Research article by Bauke et al. on p. 2184.
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IN THIS ISSUE
SPOTLIGHTS
An interview with Deepak Srivastava
Summary: We asked Deepak Srivastava, Distinguished Professor at UCSF, about his career as an active clinician, research group leader and Director of the Gladstone Institute of Cardiovascular Disease.
An interview with Rudolf Jaenisch
Summary: We recently interviewed Rudolph Jaenisch, Professor of Biology at MIT, to find out about his career, his perspective on the stem cell field and his goals as president of the ISSCR.
DEVELOPMENT AT A GLANCE
Neuronal polarization
Summary: This short review and accompanying poster highlight recent advances in our understanding of the molecular mechanisms underlying axon and dendrite specification in vitro and in vivo.
REVIEWS
Orchestrating liver development
Summary: This review summarises the complex interplay between cellular lineages, signalling pathways, and transcriptional programs necessary to form a vertebrate liver.
Adding a spatial dimension to postnatal ventricular-subventricular zone neurogenesis
Summary: This review highlights the contribution of geometry to the regulation of the neurogenic niche in the mouse and human adult brain for continuous neuronal replacement throughout life.
STEM CELLS AND REGENERATION
Brachyury and SMAD signalling collaboratively orchestrate distinct mesoderm and endoderm gene regulatory networks in differentiating human embryonic stem cells
Summary: In differentiating hESCs, BRACHYURY has cell type-specific targets and functions: it acts with SMAD1 to promote mesoderm specification, while in the endoderm it interacts with SMAD2/3.
Matrix metalloproteinase 9 modulates collagen matrices and wound repair
Highlighted article: In zebrafish, Mmp9 plays a dual role in wound repair through collagen reorganization: it is overexpressed in chronic tissue damage models and required for acute wound healing in control animals.
Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche
Summary: In maturing mouse Paneth cells, Wnt secretion is partly dependent on a Rab8a-mediated anterograde transport of Gpr177. Rab8a is required for Paneth cell maturation.
Dnmt1 is essential to maintain progenitors in the perinatal intestinal epithelium
Summary: Ablation of Dnmt1 in the mouse developing intestine leads to hypomethylation, DNA damage, premature differentiation and apoptosis. In intestinal organoid cultures, Dnmt1 is required for crypt formation.
RESEARCH ARTICLES
Innexin7a forms junctions that stabilize the basal membrane during cellularization of the blastoderm in Tribolium castaneum
Highlighted article: Cellularization in the embryo of the beetle Tribolium requires the junction protein Innexin7a, which links the basal membrane to the yolk membrane. This mechanism is distinct from that in Drosophila.
A transcriptional network controlling glial development in the Drosophila visual system
Summary: In the developing Drosophila eye, the TRF2 complex regulates downstream factors including Pdm3 and Cut to control glial proliferation and differentiation, respectively.
Intraflagellar transport 27 is essential for hedgehog signaling but dispensable for ciliogenesis during hair follicle morphogenesis
Summary: In mouse skin, depletion of the ciliary IFT27 protein impairs SMO and GLI2 trafficking and GLI processing, disrupting HH-dependent hair follicle morphogenesis, but cilia structure is preserved.
Tissue-specific roles of Fgfr2 in development of the external genitalia
Summary: The development of mouse urethral tube is a sexually dimorphic process that requires Fgfr2-mediated cell cycle progression and epithelial maturation in distinct tissue compartments.
TECHNIQUES AND RESOURCES
In vitro myelin formation using embryonic stem cells
Highlighted article: The quantitative analysis of mouse ESC-derived neurons and oligodendrocytes co-cultured in a microfluidic device provides insights into the temporal sequence of the myelination process.
CORRECTION
ARTICLES OF INTEREST IN OTHER COB JOURNALS
From Journal of Cell Science
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.