Issues
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Cover image
Cover Image
Cover: Immunofluorescent confocal image of a 1-month-old sea urchin larva (S. purpuratus). A conserved germ-line marker, Vasa (yellow), is expressed in the entire adult precursor cells during adult rudiment formation (DNA, blue). Image was revised by Julian Wong (Brown University, Providence, RI, USA). See Research article by Yajima and Wessel on p. 1960.
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IN THIS ISSUE
SPOTLIGHT
The atlas of mouse development eHistology resource
Summary: Over two decades after the publication of 'The Atlas of Mouse Development', a new online resource provides free access to the histological images and their annotations.
MEETING REVIEW
At new heights – endodermal lineages in development and disease
Summary: A recent Keystone meeting brought together researchers interested in diverse aspects of endoderm development and highlighted recent major advances in the field.
PRIMER
How to make a midbrain dopaminergic neuron
Summary: This Primer summarises recent efforts to generate human midbrain dopaminergic neurons in vitro, from pluripotent stem cells or from somatic cells via direct reprogramming.
REVIEW
The origin of the mammalian kidney: implications for recreating the kidney in vitro
Summary: This review discusses recent advances in the directed differentiation of pluripotent cells into kidney tissues, and how these inform our understanding of human renal development.
STEM CELLS AND REGENERATION
Generation of sensory hair cells by genetic programming with a combination of transcription factors
Highlighted article: Expression of Atoh1, Pou4f3 and Gfi1 in mouse embryonic stem cells efficiently induces inner ear hair cell differentiation in culture.
Essential elements for translation: the germline factor Vasa functions broadly in somatic cells
Summary: In sea urchin embryos, the germ line marker Vasa, an RNA-binding protein, acts in the soma to control mRNA translation, and is important for developmental reprogramming and wound healing.
RESEARCH REPORTS
Diversity of epithelial morphogenesis during eggshell formation in drosophilids
Highlighted article: The cellular mechanisms underlying morphogenesis of the dorsal appendages differ significantly between drosophilid species.
DEFECTIVE KERNEL 1 promotes and maintains plant epidermal differentiation
Summary: In Arabidopsis, the phytocalpain DEK1 regulates epidermal differentiation by influencing the expression of multiple members of the HD-ZIP IV transcription factor family.
Vegfa regulates perichondrial vascularity and osteoblast differentiation in bone development
Summary: In developing bone, Vegf expressed in osteolineage precursors regulates early osteoblast differentiation and blood vessel recruitment through interactions with other signalling pathways.
RESEARCH ARTICLES
Phyllotaxis involves auxin drainage through leaf primordia
Highlighted article: Leaf positioning follows a stereotyped pattern controlled by auxin distribution. Auxin drainage via the incipient midvein of leaf primordia contributes to this patterning.
The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye
Highlighted article: Yorkie, best known for controlling organ growth downstream of Hippo signalling, plays a separable role in regulating cell fate specification in the fly eye.
Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front
Summary: Single cell mRNA profiling defines a group of leading cells in migratory neural crest. Key factors expressed in these cells regulate the behaviour of the migrating neural crest population.
The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development
Summary: SCHIP1, an ankyrin-associated protein, modulates axon outgrowth and the responses of growth cones to the repulsive guidance cues Sema3F and EphB2 in mouse piriform cortex neurons.
Casz1 is required for cardiomyocyte G1-to-S phase progression during mammalian cardiac development
Summary: Cardiac-specific deletion of the para-zinc-finger protein CASZ1 in mouse embryos leads to significant heart defects associated with impaired cardiomyocyte proliferation.
Compensatory branching morphogenesis of stalk cells in the Drosophila trachea
Summary:Drosophila vATPase and mTOR pathway mutants show impaired terminal cell morphogenesis in trachea, but compensatory mechanisms partially rescue tracheal architecture.
Inhibition of Daughterless by Extramacrochaetae mediates Notch-induced cell proliferation
Summary: The bHLH transcription factor Emc acts downstream of Notch signalling to promote proliferation in the Drosophila eye by sequestering the growth suppressor Da away from its target genes.
Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo
Summary:Lhx1 mutant mice show head truncations. LHX1 regulates formation of the anterior mesendoderm tissue and limits Wnt pathway activity - acting at least partly via the protocadherin PCDH7.
CORRECTIONS
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