IN THIS ISSUE
Summary: Over two decades after the publication of 'The Atlas of Mouse Development', a new online resource provides free access to the histological images and their annotations.
Summary: A recent Keystone meeting brought together researchers interested in diverse aspects of endoderm development and highlighted recent major advances in the field.
Summary: This review discusses recent advances in the directed differentiation of pluripotent cells into kidney tissues, and how these inform our understanding of human renal development.
STEM CELLS AND REGENERATION
Highlighted article: Expression of Atoh1, Pou4f3 and Gfi1 in mouse embryonic stem cells efficiently induces inner ear hair cell differentiation in culture.
Summary: In sea urchin embryos, the germ line marker Vasa, an RNA-binding protein, acts in the soma to control mRNA translation, and is important for developmental reprogramming and wound healing.
Highlighted article: The cellular mechanisms underlying morphogenesis of the dorsal appendages differ significantly between drosophilid species.
Summary: In Arabidopsis, the phytocalpain DEK1 regulates epidermal differentiation by influencing the expression of multiple members of the HD-ZIP IV transcription factor family.
Summary: In developing bone, Vegf expressed in osteolineage precursors regulates early osteoblast differentiation and blood vessel recruitment through interactions with other signalling pathways.
Highlighted article: Leaf positioning follows a stereotyped pattern controlled by auxin distribution. Auxin drainage via the incipient midvein of leaf primordia contributes to this patterning.
The Hippo pathway effector Yki downregulates Wg signaling to promote retinal differentiation in the Drosophila eye
Highlighted article: Yorkie, best known for controlling organ growth downstream of Hippo signalling, plays a separable role in regulating cell fate specification in the fly eye.
Neural crest migration is driven by a few trailblazer cells with a unique molecular signature narrowly confined to the invasive front
Summary: Single cell mRNA profiling defines a group of leading cells in migratory neural crest. Key factors expressed in these cells regulate the behaviour of the migrating neural crest population.
The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development
Summary: SCHIP1, an ankyrin-associated protein, modulates axon outgrowth and the responses of growth cones to the repulsive guidance cues Sema3F and EphB2 in mouse piriform cortex neurons.
Summary: Cardiac-specific deletion of the para-zinc-finger protein CASZ1 in mouse embryos leads to significant heart defects associated with impaired cardiomyocyte proliferation.
Summary:Drosophila vATPase and mTOR pathway mutants show impaired terminal cell morphogenesis in trachea, but compensatory mechanisms partially rescue tracheal architecture.
Summary: The bHLH transcription factor Emc acts downstream of Notch signalling to promote proliferation in the Drosophila eye by sequestering the growth suppressor Da away from its target genes.
Context-specific function of the LIM homeobox 1 transcription factor in head formation of the mouse embryo
Summary:Lhx1 mutant mice show head truncations. LHX1 regulates formation of the anterior mesendoderm tissue and limits Wnt pathway activity - acting at least partly via the protocadherin PCDH7.