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Volume 141, Issue 1
January 2014
Issue Cover
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  • Cover image

    Cover Image

    issue cover
    Cover: Confocal image showing the adult hippocampal neurogenic niche of an adult GABAB1 receptor subunit-deficient mouse. Progenitors (BLBP, blue) and neuroblasts (Dcx, green) are aligned within the subgranular zone of the dentate gyrus. Proliferation (PCNA, red) and neurogenesis are enhanced in the hippocampus of adult GABAB1 mutant mice. See Research article by Giachino et al. on p. 83.
  • PDF Icon PDF LinkTable of contents
ISSN 0950-1991
EISSN 1477-9129

EDITORIAL

Developing with the community
Olivier Pourquié
View articletitled, Developing with the community
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DEVELOPMENT AT A GLANCE

Sphingosine 1-phosphate signalling
Karen Mendelson,Todd Evans,Timothy Hla
View articletitled, Sphingosine 1-phosphate signalling
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MEETING REVIEW

How unique is the human neocortex?
Zoltán Molnár,Alex Pollen
View articletitled, How unique is the human neocortex?
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STEM CELLS AND REGENERATION

FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney
Jennifer L. Fetting,Justin A. Guay,Michele J. Karolak,Renato V. Iozzo,Derek C. Adams,David E. Maridas,Aaron C. Brown,Leif Oxburgh
View articletitled, FOXD1 promotes nephron progenitor differentiation by repressing decorin in the embryonic kidney
Supplementary information
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Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb
Zsuzsa Agoston,Peer Heine,Monika S. Brill,Britta Moyo Grebbin,Ann-Christin Hau,Wiebke Kallenborn-Gerhardt,Jasmine Schramm,Magdalena Götz,Dorothea Schulte
View articletitled, Meis2 is a Pax6 co-factor in neurogenesis and dopaminergic periglomerular fate specification in the adult olfactory bulb
Supplementary information
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Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
Stephanie A. Hoffmann,Deniz Hos,Melanie Küspert,Richard A. Lang,Robin Lovell-Badge,Michael Wegner,Simone Reiprich
View articletitled, Stem cell factor Sox2 and its close relative Sox3 have differentiation functions in oligodendrocytes
Supplementary information
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Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity
Hideyuki Komori,Qi Xiao,Brooke M. McCartney,Cheng-Yu Lee
View articletitled, Brain tumor specifies intermediate progenitor cell identity by attenuating β-catenin/Armadillo activity
Supplementary information
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A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain
Carlene Dyer,Eric Blanc,Anja Hanisch,Henry Roehl,Georg W. Otto,Tian Yu,M. A. Basson,Robert Knight
View articletitled, A bi-modal function of Wnt signalling directs an FGF activity gradient to spatially regulate neuronal differentiation in the midbrain
Supplementary information
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The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells
Alicia R. Shields,Allyson C. Spence,Yukiko M. Yamashita,Erin L. Davies,Margaret T. Fuller
View articletitled, The actin-binding protein profilin is required for germline stem cell maintenance and germ cell enclosure by somatic cyst cells
Supplementary information
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GABA suppresses neurogenesis in the adult hippocampus through GABAB receptors
Claudio Giachino,Michael Barz,Jan S. Tchorz,Mercedes Tome,Martin Gassmann,Josef Bischofberger,Bernhard Bettler,Verdon Taylor
View articletitled, GABA suppresses neurogenesis in the adult hippocampus through GABA<sub>B</sub> receptors
Supplementary information
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CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision
Kazuo Takayama,Kenji Kawabata,Yasuhito Nagamoto,Mitsuru Inamura,Kazuo Ohashi,Hiroko Okuno,Tomoko Yamaguchi,Katsuhisa Tashiro,Fuminori Sakurai,Takao Hayakawa,Teruo Okano,Miho Kusada Furue,Hiroyuki Mizuguchi
View articletitled, CCAAT/enhancer binding protein-mediated regulation of TGFβ receptor 2 expression determines the hepatoblast fate decision
Supplementary information
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p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells
Andrei N. Mardaryev,Michal R. Gdula,Joanne L. Yarker,Vladimir N. Emelianov,Krzysztof Poterlowicz,Andrey A. Sharov,Tatyana Y. Sharova,Julie A. Scarpa,Pierre Chambon,Vladimir A. Botchkarev,Michael Y. Fessing
View articletitled, p63 and Brg1 control developmentally regulated higher-order chromatin remodelling at the epidermal differentiation complex locus in epidermal progenitor cells
Supplementary information
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RESEARCH ARTICLE

Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
Christiane Hassel,Bingqing Zhang,Michael Dixon,Brian R. Calvi
View articletitled, Induction of endocycles represses apoptosis independently of differentiation and predisposes cells to genome instability
Supplementary information
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Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos
David Cheung,Cecelia Miles,Martin Kreitman,Jun Ma
View articletitled, Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large <em>Drosophila melanogaster</em> embryos
Supplementary information
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Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance
Kayam Chak,Alex L. Kolodkin
View articletitled, Function of the <em>Drosophila</em> receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance
Supplementary information
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β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation
Tianyu Zhao,Qini Gan,Arjun Stokes,Rhonda N. T. Lassiter,Yongping Wang,Jason Chan,Jane X. Han,David E. Pleasure,Jonathan A. Epstein,Chengji J. Zhou
View articletitled, β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation
Supplementary information
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Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference
Bambang Retnoaji,Ryutaro Akiyama,Tatsuro Matta,Yasumasa Bessho,Takaaki Matsui
View articletitled, Retinoic acid controls proper head-to-trunk linkage in zebrafish by regulating an anteroposterior somitogenetic rate difference
Supplementary information
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Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development
Teddy Fauquier,Fabrice Chatonnet,Frédéric Picou,Sabine Richard,Nicolas Fossat,Nadine Aguilera,Thomas Lamonerie,Frédéric Flamant
View articletitled, Purkinje cells and Bergmann glia are primary targets of the TRα1 thyroid hormone receptor during mouse cerebellum postnatal development
Supplementary information
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The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germline
Lucy S. Williams,Sujoy Ganguly,Philippe Loiseau,Bing Fu Ng,Isabel M. Palacios
View articletitled, The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the <em>Drosophila</em> germline
Supplementary information
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Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord
Kamana Misra,Huijun Luo,Shengguo Li,Michael Matise,Mengqing Xiang
View articletitled, Asymmetric activation of Dll4-Notch signaling by Foxn4 and proneural factors activates BMP/TGFβ signaling to specify V2b interneurons in the spinal cord
Supplementary information
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Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes
Yan Yun,Simon I. R. Lane,Keith T. Jones
View articletitled, Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes
Supplementary information
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HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of ceh-22 in C. elegans
Yukimasa Shibata,Hitoshi Sawa,Kiyoji Nishiwaki
View articletitled, HTZ-1/H2A.z and MYS-1/MYST HAT act redundantly to maintain cell fates in somatic gonadal cells through repression of <em>ceh-22</em> in <em>C. elegans</em>
Supplementary information
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TECHNIQUES AND RESOURCES

Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
Nicola A. Kearns,Ryan M. J. Genga,Metewo S. Enuameh,Manuel Garber,Scot A. Wolfe,René Maehr
View articletitled, Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells
Supplementary information
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Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish
Gabriel Musso,Murat Tasan,Christian Mosimann,John E. Beaver,Eva Plovie,Logan A. Carr,Hon Nian Chua,Julie Dunham,Khalid Zuberi,Harold Rodriguez,Quaid Morris,Leonard Zon,Frederick P. Roth,Calum A. MacRae
View articletitled, Novel cardiovascular gene functions revealed via systematic phenotype prediction in zebrafish
Supplementary information
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CORRECTION

S6K links cell fate, cell cycle and nutrient response in C. elegans germline stem/progenitor cells
Dorota Z. Korta,Simon Tuck,E. Jane Albert Hubbard
View articletitled, S6K links cell fate, cell cycle and nutrient response in <em>C. elegans</em> germline stem/progenitor cells
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Insulin signaling promotes germline proliferation in C. elegans
David Michaelson,Dorota Z. Korta,Yossi Capua,E. Jane Albert Hubbard
View articletitled, Insulin signaling promotes germline proliferation in <em>C. elegans</em>
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IN THIS ISSUE

GABAB inhibits neural stem cell proliferation
View articletitled, GABA<sub>B</sub> inhibits neural stem cell proliferation
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Tracking the causes of age-related aneuploidy
View articletitled, Tracking the causes of age-related aneuploidy
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Why timing matters during segmentation
View articletitled, Why timing matters during segmentation
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Controlling expression by nuclear position
View articletitled, Controlling expression by nuclear position
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Cargo transport: a complex tale of the kinesin tail
View articletitled, Cargo transport: a complex tale of the kinesin tail
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Regulating stem cell fate with CRISPRe
View articletitled, Regulating stem cell fate with CRISPRe
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ARTICLE OF INTEREST IN OTHER COB JOURNALS

FROM JOURNAL OF CELL SCIENCE
Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis
David G. Míguez,Estel Gil-Guiñón,Sebastián Pons,Elisa Martí
View articletitled, Smad2 and Smad3 cooperate and antagonize simultaneously in vertebrate neurogenesis
The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse
Daniel L. Yamamoto,Carmen Vitiello,Jianlin Zhang,David S. Gokhin,Alessandra Castaldi,Gerald Coulis,Fabio Piaser,Maria Carmela Filomena,Peter J. Eggenhuizen,Paolo Kunderfranco,Serena Camerini,Kazunori Takano,Takeshi Endo,Marco Crescenzi,Pradeep K. L. Luther,Richard L. Lieber,Ju Chen,Marie-Louise Bang
View articletitled, The nebulin SH3 domain is dispensable for normal skeletal muscle structure but is required for effective active load bearing in mouse
Accepted manuscripts
Chemokine-like Orion is involved in the transformation of glial cells into phagocytes in different developmental neuronal remodeling paradigms
Clarisse Perron, Pascal Carme, Arnau Llobet Rosell, Eva Minnaert, Salomé Ruiz Demoulin, Héloïse Szczkowski, Lukas Jakob Neukomm, Jean-Maurice Dura, Ana Boulanger
The CCR4-NOT complex suppresses untimely translational activation of maternal mRNAs
Shou Soeda, Masaaki Oyama, Hiroko Kozuka-Hata, Tadashi Yamamoto
The Tbx20-TLE interaction is essential for the maintenance of the second heart field
Whitney Edwards, Olivia K. Bussey, Frank L. Conlon
A CDC-42-regulated actin network contributes to nuclear migration through constricted spaces in C. elegans
Jamie Ho, Leslie A. Guerrero, Diana Libuda, G. W. Gant Luxton, Daniel A. Starr
The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border
Ankita Thawani, Helen R. Maunsell, Hongyuan Zhang, Harinarayana Ankamreddy, Andrew K. Groves
More accepted manuscripts

Development presents... live stream of our Journal Meeting

Development presents advert outlining details of the live stream. 

Watch a session from Development’s Journal Meeting, Unconventional and Emerging Experimental Organisms in Cell and Developmental Biology which was live on the Node Monday 18 September.

Navigating a research career with a disability

Images showing resources which can aid disabled researchers in the lab. Red Dycem tape enhances the grip of objects, such as this 500 ml bottle, making it easier to open bottles and lift heavier objects, and provides stability for fine motor tasks. The height-adjustable black armrest provides support at the lab bench. It can be used to provide stability during fine motor tasks (such as dissections) or decrease fatigue from repetitive tasks, such as pipetting. 

Our two recent Perspectives articles explore the lived experiences of disabled scientists in our community. Kelsey L. Anbuhl and colleagues describe the lived experiences of five biologists who share the challenges and successes of undertaking a scientific career with a disability. Whereas Jack Darius Morgan reviews the literature exploring disabled scientists’ experiences in academia.

Focus on regeneration

Transverse sections of ventricles isolated from fish in the experiment illustrated in B, fluorescently stained for pS6 and F-actin. The areas that are shown at higher magnification are outlined. n≥5. 

Tissue regeneration is a fascinating phenomenon, but the cellular and molecular mechanisms underlying regeneration remain incompletely understood. Here, Development has collated a series of articles showcasing some of the most recent advances in regenerative biology.

Keeping up with the Node: Lab meetings

Keep up with the Node 'Lab meeting' posts as the platform regularly highlights development and stem cell biology labs from across the globe and showcases research and researchers from the community. August featured the Nichols lab at the University of Edinburgh, read their 'Lab meeting' article here.

Read & Publish Open Access publishing: what authors say

We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.

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