Issues
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Cover image
Cover Image
Cover: Scanning electron microscopy image of an embryonic day 10.5 mouse embryo lacking the transcription factor Grhl2, and also one allele of the soluble morphogen noggin (Grhl2−/−;Nog+/−). This image represents a partial rescue of the Grhl2−/− open neural tube phenotype, via reduction of the elevated expression of noggin in these embryos. See Research article by de Vries at al. (dev202420).
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RESEARCH HIGHLIGHT
PERSPECTIVES
INTERVIEWS
REVIEW
Functional consequences of somatic polyploidy in development
Summary: This Review explores the functions of polyploidy during multicellular development, displaying common features of polyploid cell types and highlighting differences between developmentally programmed and induced polyploidy.
RESEARCH REPORT
Grainyhead-like 2 interacts with noggin to regulate tissue fusion in mouse
Summary: Genetic reduction of elevated noggin expression in Grhl2−/− embryos leads to rescue of epithelial morphology and partially restores maxillary prominence size and neural tube closure.
RESEARCH ARTICLES
ING4 and ING5 are essential for histone H3 lysine 14 acetylation and epicardial cell lineage development
Summary: The chromatin-binding proteins ING4 and ING5 perform essential overlapping roles in cell fate decisions during mouse heart development and are required for the expression of key developmental control genes.
Sexually dimorphic dynamics of the microtubule network in medaka (Oryzias latipes) germ cells
Summary: A dome-shaped microtubule structure is identified in medaka that is present prior to sex determination in primordial germ cells and is maintained in females, contributing to oocyte polarity.
Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression and repressing neural genes in the mesoderm
Summary: Sall4 regulates posterior trunk mesoderm development by promoting mesodermal gene expression while negatively regulating expression of WNT signaling repressors and neural genes within the mesoderm.
Exploiting spatiotemporal regulation of FZD5 during neural patterning for efficient ventral midbrain specification
Highlighted Article: A tailored synthetic growth factor that selectively activates the FZD5:LRP6 receptor complex patterns neural progenitor cells into midbrain fate and gives rise to functional dopaminergic neurons in vitro and in vivo.
Multifaceted effects on even-skipped transcriptional dynamics upon Krüppel dosage changes
Summary: Changes in transcriptional dynamics of even-skipped upon halving Krüppel dosage reveal how the combination of direct transcription factor (TF)-DNA and indirect TF-TF interactions shape proper patterning.
Mitochondrial morphology dynamics and ROS regulate apical polarity and differentiation in Drosophila follicle cells
Summary: Mitochondrial fission protein Drp1 regulates epithelial follicle cell differentiation in Drosophila oogenesis. Increasing ROS and mitochondrial fragmentation suppresses the defects in epithelial polarity, and differentiation in Drp1-depleted follicle cells.
ETS transcription factors regulate precise matrix metalloproteinase expression and follicle rupture in Drosophila
Summary: Genetic analysis reveals that the ETS transcription factors Pnt and Yan fine-tune the expression of matrix metalloproteinase 2 (MMP2) during late oogenesis and follicle rupture in Drosophila melanogaster.
EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells
Summary: EphB1 controls long-range cortical axon guidance through a cell non-autonomous role in GABAergic cells. EphB1 is also required to prevent cortical and striatal axons from extending along developing ventral telencephalic vasculature.
CORRECTIONS
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.