DEVELOPMENT AT A GLANCE
Summary: This Review analyses the common principles by which vertebrates generate overall similar cup-shaped eyes, pointing to relevant differences and discussing the relationship with congenital eye malformations.
STEM CELLS AND REGENERATION
Summary: Non-dividing niche cells in the adult Drosophila testis, which are able to divide to replace missing stem cells, are unable to replace themselves.
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naïve pluripotent stem cells
Highlighted Article: Establishing that NANOGP1 has retained partial functional conservation with its ancestral copy NANOG sheds light on the role of gene duplication and subfunctionalisation in human pluripotency and development.
Summary: Adar1 prevents aberrant activation of the Mavs-mediated innate immune pathway in the pancreas, thereby maintaining pancreatic homeostasis.
Primordial germ cells adjust their protrusion type while migrating in different tissue contexts in vivo
Highlighted Article: Germ cells migrating in vivo alter the dynamic parameters of the protrusions they form in different cellular contexts and respond to differences in cortical tension in neighboring cells.
Psi promotes Drosophila wing growth via direct transcriptional activation of cell cycle targets and repression of growth inhibitors
Summary: Psi orchestrates wing growth in Drosophila via direct transcriptional activation of pro-proliferative genes in combination with repression of growth inhibitory pathways.
Summary: In Caenorhabditis elegans, the centralspindlin complex components CYK-4 and ZEN-4, together with RHO-1 and CDC-42, shape the spermatheca by controlling the completion of cytokinesis.
Summary: ARL13B, a protein enriched in a signaling hub (cilia), is required for the maturation of neurons in the mouse nose and its loss impairs smell.
Actomyosin-mediated cellular tension promotes Yap nuclear translocation and myocardial proliferation through α5 integrin signaling
Summary: ROCK-regulated nonmuscle myosin contractility couples signals from integrin to Yap in an integrated mechanochemical signaling system to ultimately control cardiomyocyte proliferation in the newborn mouse heart.
Summary: The non-receptor tyrosine kinase Src42A regulates embryonic axis elongation by multiple mechanisms, including the control of E-cadherin dynamics at adherens junctions.
Summary: Genome-edited rat models reveal that the kinase AKT1 and the AKT1 substrate FOXO4 act in a reciprocal manner to regulate development of the hemochorial placenta.
Summary: How different neuronal cell types are produced at specific times during development remains unclear. This study provides evidence that the zinc-finger protein Ikzf4 contributes to temporal patterning in the retina.
TECHNIQUES AND RESOURCES
Summary: A combinatorial and sequential one-shot approach termed ‘inception’ is a twist on base editing that allows initially inaccessible nucleotides to be reached.