Issues

Summary: A survey of germ granules across organisms and developmental stages, highlighting emerging themes regarding granule regulation, dynamics and proposed functions.

Summary: This Review analyses the common principles by which vertebrates generate overall similar cup-shaped eyes, pointing to relevant differences and discussing the relationship with congenital eye malformations.

Summary: Non-dividing niche cells in the adult Drosophila testis, which are able to divide to replace missing stem cells, are unable to replace themselves.

Highlighted Article: Establishing that NANOGP1 has retained partial functional conservation with its ancestral copy NANOG sheds light on the role of gene duplication and subfunctionalisation in human pluripotency and development.

Summary: Adar1 prevents aberrant activation of the Mavs-mediated innate immune pathway in the pancreas, thereby maintaining pancreatic homeostasis.

Highlighted Article: Germ cells migrating in vivo alter the dynamic parameters of the protrusions they form in different cellular contexts and respond to differences in cortical tension in neighboring cells.

Summary: Psi orchestrates wing growth in Drosophila via direct transcriptional activation of pro-proliferative genes in combination with repression of growth inhibitory pathways.

Summary: In Caenorhabditis elegans, the centralspindlin complex components CYK-4 and ZEN-4, together with RHO-1 and CDC-42, shape the spermatheca by controlling the completion of cytokinesis.

Summary: ARL13B, a protein enriched in a signaling hub (cilia), is required for the maturation of neurons in the mouse nose and its loss impairs smell.

Summary: ROCK-regulated nonmuscle myosin contractility couples signals from integrin to Yap in an integrated mechanochemical signaling system to ultimately control cardiomyocyte proliferation in the newborn mouse heart.

Summary: The non-receptor tyrosine kinase Src42A regulates embryonic axis elongation by multiple mechanisms, including the control of E-cadherin dynamics at adherens junctions.

Summary: Genome-edited rat models reveal that the kinase AKT1 and the AKT1 substrate FOXO4 act in a reciprocal manner to regulate development of the hemochorial placenta.

Summary: How different neuronal cell types are produced at specific times during development remains unclear. This study provides evidence that the zinc-finger protein Ikzf4 contributes to temporal patterning in the retina.

Summary: A combinatorial and sequential one-shot approach termed ‘inception’ is a twist on base editing that allows initially inaccessible nucleotides to be reached.