Organ formation relies on the orchestration of pattern formation, proliferation and growth during development. How these processes are integrated at individual cell level remains unclear. Studies using Drosophila wing imaginal discs as a model system have provided valuable insights into pattern formation, growth control and regeneration in the past decades. Here we provided single cell transcriptomic landscapes of pattern formation, proliferation and growth of wing imaginal discs. We found that patterning information is robustly maintained in the single cell transcriptomic data and can provide reference matrices to computationally map single cells into discrete spatial domains. Assignment of wing disc single cells to spatial sub-regions facilitates examination of patterning refinement processes. We also clustered single cells into different proliferation and growth states and evaluated the correlation between cell proliferation/growth states and spatial patterning. Furthermore, the single cell transcriptomic analysis allowed us to quantitatively examine the disturbance of differentiation, proliferation and growth in a well-established tumor model. We made a database to explore these datasets at: http://drosophilayanlab-virtual-wingdisc.ust.hk:3838/v2/
Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs
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Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
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Journal Meeting: From Stem Cells to Human Development
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This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
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We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
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