The embryonic origin of distinct fat depots and the role for ontogeny in specifying the functional differences among adipocyte lineages between and within depots is unclear. Using a Cre/Lox-based strategy to track the fate of major mesodermal subcompartments in mice we present evidence that fewer than 50% of interscapular brown adipocytes are derived from progenitors of the central dermomyotome. Furthermore, we demonstrate that depot-specific adipocyte lineages spatially diverge as early as gastrulation and that perigonadal adipocytes arise from separate mesodermal subcompartments in males and females. Last, we show adipocyte precursors (APs) of distinct lineages within the same depot exhibit indistinguishable responses to a high fat diet, indicating ontogenetic differences between APs do not necessarily correspond to functional differences in this context. Altogether, these findings shed light on adipose tissue patterning and suggest the behavior of adipocyte lineage cells is not strictly determined by developmental history.
A mesodermal fate map for adipose tissue
Currently Viewing Accepted Manuscript - Newer Version Available
Zachary L. Sebo, Elise Jeffery, Brandon Holtrup, Matthew S. Rodeheffer; A mesodermal fate map for adipose tissue. Development 2018; dev.166801. doi: https://doi.org/10.1242/dev.166801
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