Bone Morphogenetic Protein (BMP) signaling has been implicated in regulation of patterning of the forebrain and as a regulator of neurogenesis and gliogenesis in the mammalian cortex. However, its role in regulating other aspects of cortical development in vivo remains unexplored. We hypothesized that BMP signaling may regulate additional processes during the development of cortical neurons after observing the presence of active BMP signaling in a spatio-temporally dynamic pattern in the mouse cortex. Our investigation revealed that BMP signaling specifically regulates migration, polarity and the dendritic morphology of upper layer cortical neurons born at E15.5. On further dissection of the role of canonical and non-canonical BMP signaling in each of these processes, we found that migration of these neurons is regulated by both canonical and non-canonical BMP signaling. Their polarity however appears to be affected more strongly by canonical BMP signaling while dendritic branch formation appears to be somewhat more strongly affected by LIMK-mediated non-canonical BMP signaling.
Perturbation of canonical and non-canonical BMP signaling affects migration, polarity and dendritogenesis of mouse cortical neurons
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
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Journal Meeting: From Stem Cells to Human Development
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Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.
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