The introduction of recombinant DNA into mouse embryos has proved to be a useful technique in addressing a number of important developmental questions, e.g. the identification of DNA sequences controlling tissue-specific gene expression and the role of genes in growth control (for reviews see Palmiter & Brinster, 1985; Wagner & Stewart, 1986). Currently the favoured method for gene transfer into mice is by DNA injection into a pronucleus of the fertilized egg. However an alternative method is to exploit retroviruses as vectors for introducing genes either directly into embryos or into embryonal carcinoma (EC) or embryonic stem (ES) cells which can then be used to form chimaeric mice (Bradley, Evans, Kaufman & Robertson, 1984). There are a number of advantages to using retroviral vectors, the major one being that they can infect a wide variety of cells at an efficiency approaching 100 %.
Pathway to Independence programme
We’re excited to announce our new Pathway to Independence programme, aimed at supporting postdocs as they go on the job market. Find out more about the scheme in our Editorial.
Call for papers: Metabolic and Nutritional Control of Development and Regeneration
We are welcoming submissions for our next special issue, which will focus on metabolic and nutritional control of development and regeneration. Submission deadline: 15 May 2023.
Webinar: Increasing the visibility and impact of your research
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Would you like to increase the visibility and impact of your research and raise your profile internationally? If so, register for the very practical webinar we are running in association with HUBS on 23 February 2023.
Transitions in development: Daniel Grimes
Daniel Grimes’s lab studies the consequences of ciliary mutations, including left-right patterning defects and scoliosis. We interviewed Daniel to find out more about his career path, his experience of becoming a group leader and the influence of Jurassic Park.
Preprints in Development
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As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
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