The segment polarity gene hedgehog plays a central role in cell patterning during embryonic and post-embryonic development of the dipteran, Drosophila melanogaster. Recent studies have identified a family of hedgehog related genes in vertebrates; one of these, Sonic hedgehog is implicated in positional signalling processes that show interesting similarities with those controlled by its Drosophila homologue.
The hedgehog gene family in Drosophila and vertebrate development
Present address: Institute of Medical Biology, Dept. of Biochemistry, University of Tromsø, 9037 Tromsø, Norway.
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Michael J. Fietz, Jean-Paul Concordet, Robert Barbosa, Randy Johnson, Stefan Krauss, Andrew P. McMahon, Cliff Tabin, Philip W. Ingham; The hedgehog gene family in Drosophila and vertebrate development. Development 1 January 1994; 1994 (Supplement): 43–51. doi: https://doi.org/10.1242/dev.1994.Supplement.43
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