Diabetes carries a major health burden worldwide, and improving treatment and management of the disease requires an in-depth understanding of the development, homeostasis and physiology of the pancreas and of β-cells. Much of our knowledge to date comes from studies in the mouse, but there are significant differences between mouse and human, and it is unclear to what extent principles learned in the mouse can be applied to human. The pig represents a potentially better model than mouse, but very little is known about pig pancreas development. Here, Seung Kim and colleagues report a detailed transcriptomic and morphological analysis of pig pancreatic islets at various stages of development – revealing close similarities to human cells in terms of transcriptional profile and islet formation. They also find new evidence for developmental signalling between islet cells, providing a platform for discovering key signals controlling islet growth, survival and functional maturation. These data provide a valuable resource for the further development of the pig as a system for understanding pancreatic development, which could improve efforts in islet cell replacement and modelling diabetes.
Pancreatic development in the pig
- Split-screen
- Views Icon Views
-
Article Versions Icon
Versions
- Version of Record 30 March 2020
- Share Icon Share
-
Tools Icon
Tools
- Search Site
Pancreatic development in the pig. Development 15 March 2020; 147 (6): e0604. doi:
Download citation file:
Advertisement
Cited by
Development Journal Meeting 2022: From Stem Cells to Human Development
-JournalMeeting.png?versionId=3737)
Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Special Issue: The Immune System in Development and Regeneration
(update)-ImmuneSI.png?versionId=3737)
Our latest special issue is now complete. It showcases articles that add to the repertoire of immune cell functions during development, repair and regeneration, and provide insights into the developmental pathways leading to the generation and dispersal of these cells.
Propose a new Workshop
-GSWorkshop.png?versionId=3737)
Our Workshops bring together leading experts and early-career researchers from a range of scientific backgrounds. Applications are now open to propose Workshops for 2024, one of which will be held in a Global South country.
Preprints in Development
(update)-InPreprints.png?versionId=3737)
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context. You can read the first article here.
FocalPlane Network launched
-FocalPlaneNetworkLaunch.png?versionId=3737)
Like the Node Network, the aim of the FocalPlane Network is to facilitate promotion and networking as well as assist those seeking conference speakers, committee members, reviewers or collaborators. We hope that it will help promote diversity in the community. Find out more and join the Network here.