Loss of epithelial polarity redirects Notch signaling and triggers a Xrp1 response during neoplastic growth in Drosophilaby Logeay et al.

Invasive Procedure: new insights into how changes in epithelial structure can turn Notch nasty.

Selected by Sally Lowell. Read the guest preLight here

Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRDby Ragheb et al.

NuRD on the wire: balancing pluripotency and differentiation in mice and human cells.

Selected by Gabriel Aughey. Read the preLight here

Hedgehog signaling is required for endomesodermal patterning and germ cell development in Nematostella vectensisby Chen et al.

On the (h)edge: the germline precursors of a basal metazoa are induced at the interface between Hedgehog signalling domains.

Selected by Paul Gerald L. Sanchez and Stefano Vianello. Read the preLight here

DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiationby Pernaute et al.

Higher sensitivity to apoptosis driven by mitochondrial dynamics: Lowering of the apoptotic threshold in the post-implantation embryo is regulated by changes in mitochondrial shape and connectivity.

Selected by Katarzyna Kuzmicz-Kowalska. Read the preLight here

Membrane tension mediated mechanotransduction drives fate choice in embryonic stem cellsby De Belly et al.


Cell surface mechanics gate stem cell differentiationby Bergert et al.

Fate choice at the cell's edge: Two complimentary preprints show that plasma membrane tension regulates stem cell fate.

Selected by Joseph Jose Thottacherry. Read the preLight here

Mechanical control of morphogenesis robustnessby Martin et al.

Feel the force - anisotropic tissue tension, away from cell shape changes, is essential for morphogenesis robustness in Drosophila leg formation.

Selected by Helen Zenner. Read the preLight here

Trophectoderm Potency is Retained Exclusively in Human Naïve Cellsby Guo et al.

Regretting lineage decisions: Human naïve cells and the inner cell mass from human blastocysts retain the potential to generate trophectoderm-like cells.

Selected by Sergio Menchero. Read the preLight here

Six new reference-quality bat genomes illuminate the molecular basis and evolution of bat adaptationsby Jebb et al.

Light up the night: six bat genomes illuminate the origin and adaptation of bats.

Selected by Alexa Sadier. Read the preLight here

Regeneration in the adult Drosophila brainby Crocker et al.

A hidden stem cell-like population found in the Drosophila brain: let's regenerate.

Selected by Ivana Viktorinová. Read the preLight here

KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiationby Li et al.

Unleash the chromatin! Global loss of methylation is essential for effective T cell responses.

Selected by Jonny Coates. Read the preLight here

Mutational signatures are jointly shaped by DNA damage and repairby Volkova et al.

A combinatory mutational screen in C. elegans, combining 54 DNA repair mutants and 12 genotoxins, demonstrates that mutations are a result of both DNA damage and failed repair.

Selected by Kerryn Elliott. Read the preLight here