Loss of epithelial polarity redirects Notch signaling and triggers a Xrp1 response during neoplastic growth in Drosophila by Logeay et al.
Invasive Procedure: new insights into how changes in epithelial structure can turn Notch nasty.
Differential regulation of lineage commitment in human and mouse primed pluripotent stem cells by NuRD by Ragheb et al.
NuRD on the wire: balancing pluripotency and differentiation in mice and human cells.
Hedgehog signaling is required for endomesodermal patterning and germ cell development in Nematostella vectensis by Chen et al.
On the (h)edge: the germline precursors of a basal metazoa are induced at the interface between Hedgehog signalling domains.
DRP1-mediated regulation of mitochondrial dynamics determines the apoptotic response upon embryonic differentiation by Pernaute et al.
Higher sensitivity to apoptosis driven by mitochondrial dynamics: Lowering of the apoptotic threshold in the post-implantation embryo is regulated by changes in mitochondrial shape and connectivity.
Membrane tension mediated mechanotransduction drives fate choice in embryonic stem cells by De Belly et al.
Cell surface mechanics gate stem cell differentiation by Bergert et al.
Fate choice at the cell's edge: Two complimentary preprints show that plasma membrane tension regulates stem cell fate.
Mechanical control of morphogenesis robustness by Martin et al.
Feel the force - anisotropic tissue tension, away from cell shape changes, is essential for morphogenesis robustness in Drosophila leg formation.
Trophectoderm Potency is Retained Exclusively in Human Naïve Cells by Guo et al.
Regretting lineage decisions: Human naïve cells and the inner cell mass from human blastocysts retain the potential to generate trophectoderm-like cells.
Six new reference-quality bat genomes illuminate the molecular basis and evolution of bat adaptations by Jebb et al.
Light up the night: six bat genomes illuminate the origin and adaptation of bats.
Regeneration in the adult Drosophila brain by Crocker et al.
A hidden stem cell-like population found in the Drosophila brain: let's regenerate.
KDM6B-dependent chromatin remodelling underpins effective virus-specific CD8+ T cell differentiation by Li et al.
Unleash the chromatin! Global loss of methylation is essential for effective T cell responses.
Mutational signatures are jointly shaped by DNA damage and repair by Volkova et al.
A combinatory mutational screen in C. elegans, combining 54 DNA repair mutants and 12 genotoxins, demonstrates that mutations are a result of both DNA damage and failed repair.