A Scube2-Shh feedback loop links morphogen release to morphogen signaling to enable scale invariant patterning of the ventral neural tubeby Collins et al.

Size matters: a size-dependent factor that scales sonic hedgehog morphogen gradient in early DV patterning.

Selected by Teresa Rayon. Read the preLight here

Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophilaby Seller et al.

Cell cycle speed sets the pace for heterochromatin formation.

Selected by Gabriel Aughey. Read the preLight here

Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cordby Delile et al.

Using single-cell RNA sequencing on early mouse embryonic stages, the authors recapitulate the development of the neural tube and unravel the molecular mechanisms that underlie spatial and temporal neuronal diversity in the spinal cord.

Selected by Reena Lasrado. Read the preLight here

Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinomaby Palamidessi et al.

Endocytic growth factor signaling induces proliferation and solid-to-liquid transitions in confluent epithelial tissues in 2D and 3D cell culture.

Selected by Tim Fessenden. Read the preLight here

Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domainsby Leemans et al.

It's not always one or the other: promoter sequence and local environment help gene repression and expression in heterochromatin.

Selected by Carmen Adriaens and Clarice Hong. Read the preLight here

Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive elimination of unspecified cellsby Hashimoto & Sasaki

Differentiate or die! A new role for cell competition and Hippo signalling in the early mouse embryo.

Selected by Sarah Bowling and Teresa Rayon. Read the preLight here

Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individualsby Mahmoudi et al.

Growing older and wiser: researchers reveal a subset of old fibroblasts that promote reprogramming more efficiently than their counterparts.

Selected by Shikha Nayar. Read the preLight here

Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cellsby Saikia et al.


High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytesby Singh et al.

What's all the RAGE: DARTing into uncharted droplet-based scRNA-seq territory.

Selected by Samantha Seah. Read the preLight here

The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent mannerby Germani et al.

To win or to lose: infection affects epithelial tissue growth and cell survival in a Toll dependent manner.

Selected by Rohan Khadilkar. Read the preLight here

Systematic identification of human SNPs affecting regulatory element activityby van Arensbergen et al.

Assessing the regulatory potential of human genetic variation: use of Massively Parallel Reporter Assays to identify >30,000 SNPs that modulate reporter expression.

Selected by Jesus Victorino. Read the preLight here

DNA microscopy: Optics-free spatio-genetic imaging by a stand-alone chemical reactionby Weinstein et al.

DNA microscopy: imaging biology through the lens of DNA sequencing.

Selected by Theo Sanderson. Read the preLight here