The Six family transcription factors Six1 and Six2 play non-overlapping roles during kidney development in mice: Six1 controls the initial formation of nephron progenitors, which give rise to nephrons (the functional units of the kidney), whereas Six2 controls progenitor self-renewal. How these factors function during kidney development in humans, however, is less clear. Now, Lori O'Brien, Anton Valouev, Andrew McMahon and co-workers reveal that mouse and human nephron progenitors are differentially regulated by Six family factors (p. 595). Using ChIP-seq analyses, they show that, although mouse Six2 and human SIX2 share many common targets, the SIX1 gene is a unique SIX2 target in humans. In line with this, they demonstrate that Six1 expression is transient and independent of Six2 in the mouse embryonic kidney, whereas SIX1 expression persists in human fetal nephron progenitors and is regulated by SIX2. The researchers also show that SIX1 and SIX2 exhibit overlapping activities in human fetal nephron progenitors, binding to similar sets of targets and showing evidence of cross-regulatory activity. These findings highlight a divergence in Six family function that may underlie species-specific differences in kidney development, such as the extended period of nephrogenesis seen in humans.
Kidney development: of mice and men
- Split-screen
- Views Icon Views
-
Article Versions Icon
Versions
- Version of Record 15 February 2016
- Share Icon Share
-
Tools Icon
Tools
- Search Site
Kidney development: of mice and men. Development 15 February 2016; 143 (4): e0402. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.