Anteroposterior polarity in the C. elegans embryo begins with the sperm-induced formation of an anterior cortical actomyosin cap and the asymmetric cortical localisation of the PAR polarity proteins. The subsequent accumulation of the zinc finger protein MEX-5 in the anterior cytoplasm converts this cortical asymmetry into cytoplasmic mRNA and protein asymmetries, but what establishes MEX-5 asymmetry? Tenlen and co-workers now uncover a novel link between the PAR polarity proteins and this asymmetry (see p. 3665). MEX-5 has restricted mobility before fertilisation and in the anterior of one-cell embryos, they report, but in the embryo's posterior its mobility increases as asymmetry develops. They show that a C-terminal domain is required for this increased mobility and identify a crucial residue (Ser458) in the domain that is phosphorylated in vivo. Because the kinase activities of PAR-1 and PAR-4 are required to phosphorylate this residue, the researchers suggest that its phosphorylation might be the elusive link between the PAR proteins and the cytoplasmic asymmetry of MEX-5.
MEX-5 takes its PARtners for asymmetry
MEX-5 takes its PARtners for asymmetry. Development 15 November 2008; 135 (22): e2201. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.