The developing vertebrate hindbrain is subdivided into functional segments called neuromeres. Cells can mix within but not between neuromeres –so-called lineage restriction – a process discovered in Drosophila wing development. Langenberg and Brand now reveal that brain segmentation extends at least as far as the midbrain-hindbrain boundary(mhb) region in zebrafish (see p. 3209). The researchers used continuous single cell analysis in a GFP transgenic zebrafish line to trace the movement of nuclei in the developing mhb region and analyzed the final position of each nucleus with an antibody against Otx, a midbrain marker. Their results identify a lineage restriction boundary in the mhb region that is probably established during late gastrulation. Lineage restriction between these regions may serve to constrain the mhb organizer cell population during brain development, conclude the researchers. Such a link has been well studied in flies but poorly characterized in vertebrate brain development.
Lineage restriction: from fly wing to vertebrate brain
Lineage restriction: from fly wing to vertebrate brain. Development 15 July 2005; 132 (14): e1402. doi:
Download citation file:
Advertisement
Cited by
Development Journal Meeting 2022: From Stem Cells to Human Development
-JournalMeeting.png?versionId=3939)
Following a virtual meeting in 2020, we are delighted to announce that the fifth iteration of our popular Journal Meeting will be held from 11-14 September 2022 at the historic Wotton House, Surrey. Registration is open now.
Preprints in Development
(update)-InPreprints.png?versionId=3939)
As part of our efforts to support the use of preprints and help curate the preprint literature, we are delighted to launch a new article type: ‘In preprints’. These pieces will discuss one or more recent preprints and place them in a broader context.
Submit your next Techniques and Resources paper to Development
-TechniquesAndResources.png?versionId=3939)
Development regularly publishes Techniques and Resources papers. These manuscripts describe a novel technique, a substantial advance of an existing technique, or a new resource that will have a significant impact on developmental biology research. Find out more here.
Transitions in development: Rashmi Priya
(update)-RashmiPriya.png?versionId=3939)
Rashmi Priya’s research group uses the zebrafish heart as a model system to understand the complex morphogenetic events of organogenesis. We interviewed Rashmi to learn about her career path so far, and to discuss the challenges of starting a lab in the middle of a global pandemic.
The Node Network
-NodeNetwork.png?versionId=3939)
The Node Network is a global directory of developmental and stem cell biologists, designed to help you find speakers, referees, panel members and potential collaborators. Find out more about the Node Network.