Heart malformations are among the commonest human inborn defects. But,although some of the genes involved in vertebrate heart morphogenesis have been identified, little is known about the specification of heart progenitors. On p. 2533, Satou and co-workers report that in the ascidian Ciona savignyi, a primitive chordate, Cs-Mesp specifies heart precursor cells. Cs-Mesp is the sole Ciona orthologue of the vertebrate Mesp genes, which have been implicated in heart development. The researchers show that Cs-Mesp is specifically and transiently expressed in embryonic heart progenitor cells in C. savignyi, and that knockdown of its expression blocks heart development. In addition, Cs-Mesp drives the expression of genes, including Nkx and HAND, that are essential for vertebrate heart development. Although the ascidian heart is simpler than the vertebrate heart, these results suggest that the mechanism for heart specification is conserved among chordates.
The heart of the matter
The heart of the matter. Development 1 June 2004; 131 (11): e1102. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.