During gastrulation, the blastula organises into three germ layers in a process that is dependent on the establishment of cell polarity and directed cell migration. Ulrich and co-workers use detailed confocal imaging of cell movement and morphology to show that Silberblick (Slb), the zebrafish orthologue of Wnt11, controls hypoblast morphogenesis and cell migration at the onset of zebrafish gastrulation (see p. 5375). In slb mutant embryos, hypoblast cells in the forming germ ring still move in the correct direction but move more hesitantly than cells in wild-type embryos. These aberrant cell movements are preceded by defects in the orientation of cellular processes. The Wnt signalling pathway is also important at later stages of gastrulation and, say the researchers, additional studies will show whether it acts through the same target processes in both early and late gastrulation.
Fishy gastrulation movements controlled by Slb/Wnt11 signalling
Fishy gastrulation movements controlled by Slb/Wnt11 signalling. Development 15 November 2003; 130 (22): e2203. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.