Because the achaete-scute (ac/sc) genes seem to initiate nervous system development in all arthropods, knowing how their number and function varies between Arthropoda species should provide insights into the evolution of nervous system development in insects. On p. 4373, Wheeler et al. describe the ac/sc genes of the red flour beetle (Tribolium castaneum), which diverged from Drosophila ∼300 million years ago. Both species encode a single neural precursor gene -asense - which is expressed in all neural precursors. However,whereas Drosophila encodes three proneural genes (achaete,scute and lethal of scute), which promote neural precursor formation, Tribolium encodes a single proneural gene -achaete-scute homologue (Tc-ASH). Tc-ASH alone can promote neural precursor formation from ectodermal cells, but unlike achaete and scute, it plays no apparent role in the fate specification of individual neural precursors, hinting at a recent evolutionary specialisation in the Drosophila lineage.
Proneural gene evolution
Proneural gene evolution. Development 15 September 2003; 130 (18): e1804. doi:
Download citation file:
Advertisement
Cited by
Call for papers: Uncovering Developmental Diversity
Development invites you to submit your latest research to our upcoming special issue: Uncovering Developmental Diversity. This issue will be coordinated by our academic Editor Cassandra Extavour (Harvard University, USA) alongside two Guest Editors: Liam Dolan (Gregor Mendel Institute of Molecular Plant Biology, Austria) and Karen Sears (University of California Los Angeles, USA).
Choose Development in 2024
In this Editorial, Development Editor-in-Chief James Briscoe and Executive Editor Katherine Brown explain how you support your community by publishing in Development and how the journal champions serious science, community connections and progressive publishing.
Journal Meeting: From Stem Cells to Human Development
Register now for the 2024 Development Journal Meeting From Stem Cells to Human Development. Early-bird registration deadline: 3 May. Abstract submission deadline: 21 June.
Pluripotency of a founding field: rebranding developmental biology
This collaborative Perspective, the result of a workshop held in 2023, proposes a set of community actions to increase the visibility of the developmental biology field. The authors make recommendations for new funding streams, frameworks for collaborations and mechanisms by which members of the community can promote themselves and their research.
Read & Publish Open Access publishing: what authors say
We have had great feedback from authors who have benefitted from our Read & Publish agreement with their institution and have been able to publish Open Access with us without paying an APC. Read what they had to say.