A Scube2-Shh feedback loop links morphogen release to morphogen signaling to enable scale invariant patterning of the ventral neural tube by Collins et al.
Size matters: a size-dependent factor that scales sonic hedgehog morphogen gradient in early DV patterning.
Selected by Teresa Rayon. Read the preLight here
Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila by Seller et al.
Cell cycle speed sets the pace for heterochromatin formation.
Selected by Gabriel Aughey. Read the preLight here
Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord by Delile et al.
Using single-cell RNA sequencing on early mouse embryonic stages, the authors recapitulate the development of the neural tube and unravel the molecular mechanisms that underlie spatial and temporal neuronal diversity in the spinal cord.
Selected by Reena Lasrado. Read the preLight here
Unjamming overcomes kinetic and proliferation arrest in terminally differentiated cells and promotes collective motility of carcinoma by Palamidessi et al.
Endocytic growth factor signaling induces proliferation and solid-to-liquid transitions in confluent epithelial tissues in 2D and 3D cell culture.
Selected by Tim Fessenden. Read the preLight here
Promoter-intrinsic and local chromatin features determine gene repression in lamina-associated domains by Leemans et al.
It's not always one or the other: promoter sequence and local environment help gene repression and expression in heterochromatin.
Selected by Carmen Adriaens and Clarice Hong. Read the preLight here
Epiblast formation by Tead-Yap-dependent expression of pluripotency factors and competitive elimination of unspecified cells by Hashimoto & Sasaki
Differentiate or die! A new role for cell competition and Hippo signalling in the early mouse embryo.
Selected by Sarah Bowling and Teresa Rayon. Read the preLight here
Old fibroblasts secrete inflammatory cytokines that drive variability in reprogramming efficiency and may affect wound healing between old individuals by Mahmoudi et al.
Growing older and wiser: researchers reveal a subset of old fibroblasts that promote reprogramming more efficiently than their counterparts.
Selected by Shikha Nayar. Read the preLight here
Simultaneous multiplexed amplicon sequencing and transcriptome profiling in single cells by Saikia et al.
High-throughput targeted long-read single cell sequencing reveals the clonal and transcriptional landscape of lymphocytes by Singh et al.
What's all the RAGE: DARTing into uncharted droplet-based scRNA-seq territory.
Selected by Samantha Seah. Read the preLight here
The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner by Germani et al.
To win or to lose: infection affects epithelial tissue growth and cell survival in a Toll dependent manner.
Selected by Rohan Khadilkar. Read the preLight here
Systematic identification of human SNPs affecting regulatory element activity by van Arensbergen et al.
Assessing the regulatory potential of human genetic variation: use of Massively Parallel Reporter Assays to identify >30,000 SNPs that modulate reporter expression.
Selected by Jesus Victorino. Read the preLight here
DNA microscopy: Optics-free spatio-genetic imaging by a stand-alone chemical reaction by Weinstein et al.
DNA microscopy: imaging biology through the lens of DNA sequencing.
Selected by Theo Sanderson. Read the preLight here