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Keywords: Stem cells
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Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... as a model, we have recently described that adult intestinal stem cells (ISCs), do not activate programmed cell death upon aneuploidy induction, leading to an increase in ISC proliferation rate, and tissue dysplasia. How aneuploidy impacts ISCs in intestinal tumorigenic models remains to be investigated...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (10): bio058890.
Published: 14 October 2021
...Aaron M. Savage; Ramiro Alberio; Andrew D. Johnson ABSTRACT In vitro production of tissue-specific stem cells [e.g. haematopoietic stem cells (HSCs)] is a key goal of regenerative medicine. However, recent efforts to produce fully functional tissue-specific stem cells have fallen short. One...
Journal Articles
Biol Open (2021) 10 (4): bio058526.
Published: 23 April 2021
...William R. Jeffery; Špela Gorički ABSTRACT In the ascidian Ciona intestinalis , basal body parts regenerate distal structures but distal body parts do not replace basal structures. Regeneration involves the activity of adult stem cells in the branchial sac, which proliferate and produce migratory...
Journal Articles
Biol Open (2020) 9 (9): bio052381.
Published: 21 September 2020
... pathways involved in cardiac hypertrophy, there is a need for improved in vitro models. In this study, we investigated how hypertrophic stimulation affected human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (CMs). The cells were stimulated with endothelin-1 (ET-1) for 8, 24, 48, 72, or 96 h...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (11): bio046789.
Published: 12 November 2019
...Manu D. Tiwari; Daniela M. Zeitler; Gunter Meister; Andreas Wodarz ABSTRACT Stem cells can self-renew and produce daughter cells destined for differentiation. The precise control of the balance between these two outcomes is essential to ensure tissue homeostasis and to prevent uncontrolled...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (8): bio042812.
Published: 9 August 2019
.../j.ydbio.2016.10.016 Basak , O. , Beumer , J. , Wiebrands , K. , Seno , H. , van Oudenaarden , A. and Clevers , H. ( 2017 ). Induced quiescence of Lgr5+ stem cells in intestinal organoids enables differentiation of hormone-producing enteroendocrine cells . Cell Stem Cell...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (5): bio037937.
Published: 1 May 2019
...-renewing undifferentiated state akin to trophoblast stem cells described in other species. Functional features uncovered are essential for understanding early events in bovine pregnancy towards initiation of implantation. With interest in understanding physiological changes to the preimplantation embryo...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (7): 979–992.
Published: 15 July 2017
... regeneration of the neural retina and retinal pigment epithelium in the embryonic chick. Cell fate Progenitors Retinal pigment epithelium Regeneration Retina Stem cells Transdifferentiation Re-specification In vertebrates, the retinal pigment epithelium (RPE) is a single-layered pigmented...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (11): 1595–1607.
Published: 21 October 2015
...Takumi Miura; Tohru Sugawara; Atsushi Fukuda; Ryo Tamoto; Tomoyuki Kawasaki; Akihiro Umezawa; Hidenori Akutsu ABSTRACT In mice, leukemia inhibitory factor (LIF)-dependent primitive neural stem cells (NSCs) have a higher neurogenic potential than bFGF-dependent definitive NSCs. Therefore, expandable...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (12): 1236–1244.
Published: 28 November 2014
...Niraimathi Govindasamy; Supriya Murthy; Yashoda Ghanekar ABSTRACT Adult stem cells face the challenge of maintaining tissue homeostasis by self-renewal while maintaining their proliferation potential over the lifetime of an organism. Continuous proliferation can cause genotoxic/metabolic stress...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (10): 881–886.
Published: 4 September 2014
...Toma Yakulov; Ufuk Günesdogan; Herbert Jäckle; Alf Herzig ABSTRACT Stem cells continuously generate differentiating daughter cells and are essential for tissue homeostasis and development. Their capacity to self-renew as undifferentiated and actively dividing cells is controlled by either external...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (4): 341–352.
Published: 7 February 2012
... of the Creative Commons Attribution Non-Commercial Share Alike License ( http://creativecommons.org/licenses/by-nc-sa/3.0/ ). Stem cells NuRD DNA methylation Trophectoderm Chromatin The first lineage commitment event during early mammalian development results in the segregation of two distinct...
Includes: Supplementary data
Journal Articles
Biol Open (2012) 1 (3): 237–246.
Published: 3 February 2012
...Brian G. Ballios; Laura Clarke; Brenda L. K. Coles; Molly S. Shoichet; Derek Van Der Kooy Summary Self-renewing, multipotential retinal stem cells (RSCs) reside in the pigmented ciliary epithelium of the peripheral retina in adult mammals. RSCs can give rise to rhodopsin positive-cells, which can...
Includes: Supplementary data