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Keywords: Spindle assembly checkpoint
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Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... phenotypes in the Drosophila gut, we found that concomitant aneuploidy induction by impairment of the spindle assembly checkpoint (SAC) consistently leads to a more severe progression of intestinal dysplasia or tumorigenesis. This is characterized by an accumulation of progenitor cells, high tissue cell...
Includes: Supplementary data
Journal Articles
Journal Articles
Journal Articles
Biol Open (2014) 3 (6): 522–528.
Published: 29 May 2014
... missegregation, whereas its depletion in mammalian cells leads to chromosome segregation defects despite the presence of a functional spindle assembly checkpoint (SAC). Cenp-meta has previously been reported to be the Drosophila homolog of vertebrate Cenp-E. In this study, we show that cenp-metaΔ mutant...
Includes: Multimedia, Supplementary data