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Keywords: Notch signaling
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Journal Articles
Biol Open (2021) 10 (11): bio058910.
Published: 3 November 2021
..., we find a mutant, stum 9-3 , affecting the proliferation and differentiation of Drosophila adult ISCs in a forward genetic screen for factors regulating the proliferation and differentiation ISCs. stum 9-3 acts through the conserved Notch signaling pathway, upstream of the S2 cleavage of the Notch...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (1): bio047696.
Published: 10 January 2020
... to maintain GSCs relies on Dally expression. Combining yeast and fruit fly genetics, we illustrate that Dally is under the transcriptional control of Notch signaling via the transcription factor Su(H). Further, we assayed human glypicans and disease-associated variants in Drosophila ovary, which can serve...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (3): bio041095.
Published: 26 March 2019
...Mina Azimi; Nadean L. Brown ABSTRACT Notch signaling regulates a multitude of cellular processes. During ocular lens development this pathway is required for lens progenitor growth, differentiation and maintenance of the transition zone. After ligand-receptor binding, the receptor proteins...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (8): 1165–1173.
Published: 26 June 2017
... transcription. Genetic interaction experiments identified that PP4 likely promotes Notch signaling within the nucleus of the Notch-receiving cell. Although the PP4 complex is implicated in various cellular processes, its role in the regulation of Wg and Notch pathways was previously uncharacterized. Our study...
Includes: Supplementary data