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Keywords: Mitosis
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Journal Articles
Biol Open (2021) 10 (11): bio058623.
Published: 3 November 2021
... and tumorigenic phenotypes are worsened by aneuploidy induction in adult stem cells in the Drosophila intestinal epithelium. Cancer Mitosis Aneuploidy Stem cells Spindle assembly checkpoint European Regional Development Fund http://dx.doi.org/10.13039/501100008530 Fundação para...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (7): bio053322.
Published: 21 July 2020
... , V. , Boye , E. , Lopez-Aviles , S. and Grallert , B. ( 2017 ). A checkpoint-independent mechanism delays entry into mitosis after UV irradiation . J. Cell Sci.   130 , 4028 - 4037 . 10.1242/jcs.204693 Saitoh , S. and Yanagida , M. ( 2014 ). Does a shift...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (6): bio037424.
Published: 12 June 2019
... the nuclear envelope disassembles during mitosis, MCCs diffuse throughout the spindle region and cytoplasm. Here, we employed an approach using binucleate yeast zygotes to examine the localization dynamics of SAC effectors required for MCC assembly and function in budding yeast, in which the nuclear envelope...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (12): bio038307.
Published: 14 December 2018
... to asparaginase treatment. Together, these results argue that human asparagine synthetase undergoes regulated recruitment to the mitotic spindles and that it may have acquired a second role in mitosis similar to other metabolic enzymes that contribute to metabolic reprogramming in cancer cells. * Author...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (11): 1672–1679.
Published: 5 October 2017
... in cohesion fatigue, asynchronous separation of chromatids without mitotic exit ( Daum et al., 2011 ; Sivakumar et al., 2014 ; Stevens et al., 2011 ). We tested if Nuf2PP1 expression rescued mitotic defects in Ska-depleted cells. In control cells, expression of Nuf2, PP1 or Nuf2PP1 did not alter mitosis...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (6): 844–849.
Published: 28 April 2017
...Lan Lin; Li Chen; Phong T. Tran ABSTRACT Post-translational protein modification such as phosphorylation and ubiquitination are critical during mitosis to ensure proper timing and progression of chromosome segregation. It has been recently recognized that another type of protein modification...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (5): 654–663.
Published: 28 March 2017
...Jack W. C. Chen; Zhuo A. Chen; Kacper B. Rogala; Jeremy Metz; Charlotte M. Deane; Juri Rappsilber; James G. Wakefield ABSTRACT The hetero-octameric protein complex, Augmin, recruits γ-Tubulin ring complex (γ-TuRC) to pre-existing microtubules (MTs) to generate branched MTs during mitosis...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (3): 390–401.
Published: 20 January 2017
... ). However, this approach failed during anaphase of mitosis when mean displacements could be as high as 15 µm microns per 55 s ( Fig. S4C ). A set of visualization techniques, such as overlaying subsequent frames and displaying links between centroid ( Fig. S4 A-C), helped to validate tracks. Missing...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (11): 1674–1679.
Published: 15 November 2016
... of BubR1 leads to accelerated mitosis. We previously found that mutation of the KEN1-box domain of Drosophila BubR1 ( bubR1-KEN1 mutant) affects the binding of BubR1 to Cdc20, the activating co-factor of the APC/C, and does not accelerate the mitotic timing despite resulting in a defective SAC, which...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (8): 1052–1061.
Published: 24 July 2015
..., although mitosis is largely unperturbed and these embryos develop and hatch at near-normal rates. Y2H analysis reveals that PLP can potentially form multiple interactions with itself and with the PCM recruiting proteins Asl, Spd-2 and Cnn. A deletion analysis suggests that PLP participates in a complex...
Includes: Supplementary data
Journal Articles
Biol Open (2015) 4 (2): 155–169.
Published: 16 January 2015
..., large-scale immunoprecipitation and mass spectrometry, we report the first comprehensive map of mitotic phase-specific protein interactions of the microtubule-end binding protein, EB1. EB1 interacts with some, but not all, of its partners throughout mitosis. We show that the interaction of EB1...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (12): 1217–1223.
Published: 21 November 2014
... Commons Attribution License ( http://creativecommons.org/licenses/by/3.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. K-fiber Clasp Microtubules Mitosis Spindle The self-organization and maintenance...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (10): 904–912.
Published: 12 September 2014
...Takahiro Matsusaka; Maria Enquist-Newman; David O. Morgan; Jonathon Pines ABSTRACT The Anaphase Promoting Complex or Cyclosome (APC/C) is critical to the control of mitosis. The APC/C is an ubiquitin ligase that targets specific mitotic regulators for proteolysis at distinct times in mitosis...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (6): 522–528.
Published: 29 May 2014
... neuroblasts arrest in mitosis when treated with colchicine. cenp-metaΔ mutant cells display a mitotic delay. Yet, despite the persistence of the two checkpoint proteins Mad2 and BubR1 on unattached kinetochores, these cells eventually enter anaphase and give rise to highly aneuploid daughter cells. Indeed, we...
Includes: Multimedia, Supplementary data
Journal Articles
Biol Open (2013) 2 (3): 314–323.
Published: 17 January 2013
... pericentriolar proteins D-PLP, Centrosomin and γ-tubulin. They show poorly focused spindle poles that reach the plasma membrane. Despite being compromised for functional centrosome, these cells could successfully undergo mitosis. Live-cell imaging analysis of acentriolar spindle assembly revealed that nascent...
Journal Articles
Biol Open (2012) 1 (5): 422–429.
Published: 6 March 2012
.../licenses/by-nc-sa/3.0/ ). Dgp71WD Centrosome Mitosis Meiosis Bipolar spindle formation depends on MT polymerisation occurring in a spatially and temporally controlled manner. In many cell types, centrosomes are the primary MT organising centres, however centrosomes are not the only...
Includes: Multimedia, Supplementary data