... microenvironment surrounding cells and contribute biomechanical properties to connective tissues ( Fig. 1 ). However, ECM functions extend far beyond simple structural support for cells, tissues, and organs. Over the past decades, it has become increasingly clear that the ECM, via chemical and mechanical cues...

..., and injury models should enable a broad range of innovative grafting experiments that maintain the organotypic microenvironment of both host and donor tissues. Elucidating the genetic determinants and environmental factors that control neurogenesis and neuronal subtype specification may leverage novel...