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Keywords: Cilia
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Journal Articles
Biol Open bio.059267.
Published: 22 April 2022
... Attribution License ( http://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed. 3D culture Cilia Goblet cell Human nasal epithelial cells Nasal organoid Characterization...
Journal Articles
Biol Open (2021) 10 (9): bio058843.
Published: 28 September 2021
..., as ARL13B was shown to act as a guanine nucleotide exchange factor (GEF) for ARL3, it is also possible that ARL13B indirectly mediates the ciliary INPP5E localization via activating ARL3. We here show that INPP5E is delocalized from cilia in both ARL3 -knockout (KO) and ARL13B -KO cells. However, some...
Includes: Supplementary data
Journal Articles
Biol Open (2021) 10 (8): bio058531.
Published: 6 August 2021
...Suzanne H. Hodge; Amy Watts; Richard Marley; Richard A. Baines; Ernst Hafen; Lindsay K. MacDougall ABSTRACT Primary cilia are compartmentalised from the rest of the cell by a ciliary gate comprising transition fibres and a transition zone. The ciliary gate allows the selective import and export...
Journal Articles
Biol Open (2021) 10 (1): bio057653.
Published: 25 January 2021
...Hantian Qiu; Sayaka Fujisawa; Shohei Nozaki; Yohei Katoh; Kazuhisa Nakayama ABSTRACT Compositions of proteins and lipids within cilia and on the ciliary membrane are maintained to be distinct from those of the cytoplasm and plasma membrane, respectively, by the presence of the ciliary gate. INPP5E...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (10): bio054338.
Published: 5 October 2020
... and the centrosome sit side-by-side in the cell, no studies have been done to see whether these protein accumulations impede organelle function. We investigated whether the formation of aggresomes affected key centrosome functions: its ability to organise the microtubule network and to promote cilia formation. We...
Includes: Supplementary data
Journal Articles
Biol Open (2020) 9 (5): bio052027.
Published: 14 May 2020
...), but its function has remained enigmatic. Recent studies have shown that zebrafish sspo mutants develop a curved embryonic body axis. Zebrafish embryos with impaired cilia motility also develop curved bodies, which arises from failure of expression of urotensin related peptide ( urp ) genes in CSF...
Journal Articles
Biol Open (2019) 8 (9): bio043786.
Published: 17 September 2019
... of eight subunits that are encoded by the causative genes of Bardet-Biedl syndrome (BBS), has been proposed to connect the IFT machinery to ciliary membrane proteins, such as G protein-coupled receptors, to mediate their export from cilia. However, little is known about the connection between the IFT...
Includes: Supplementary data
Journal Articles
Biol Open (2019) 8 (1): bio038745.
Published: 14 January 2019
... in vitro . J. Neurobiol.   60 , 89 - 100 . 10.1002/neu.20006 Delaval , B. , Bright , A. , Lawson , N. D. and Doxsey , S. ( 2011 ). The cilia protein IFT88 is required for spindle orientation in mitosis . Nat. Cell Biol.   13 , 461 - 468 . 10.1038/ncb2202 Delmaghani...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (8): bio036012.
Published: 15 August 2018
...Rustem Uzbekov; Anastasiia Garanina; Christophe Bressac ABSTRACT The centrosome is the organizing center of microtubules in the cell, the basis for the origin of cilia and flagella and a site for the concentration of a regulatory proteins multitude. The centrosome comprises two centrioles...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (5): bio033241.
Published: 30 April 2018
... and IFT70B double-knockout cells did not form cilia, even though IFT70 is associated peripherally with the IFT-B complex via the IFT52–IFT88 dimer, and other IFT-B subunits assembled at the ciliary base in the absence of IFT70. Exogenous expression of either IFT70A or IFT70B restored the ciliogenesis defect...
Includes: Supplementary data
Journal Articles
Biol Open (2018) 7 (4): bio033944.
Published: 16 April 2018
... Chen , J. , Knowles , H. J. , Hebert , J. L. and Hackett , B. P. ( 1998 ). Mutation of the mouse hepatocyte nuclear factor/forkhead homologue 4 gene results in an absence of cilia and random left-right asymmetry . J. Clin. Invest.   102 , 1077 - 1082 . doi:10.1172/JCI4786...
Includes: Supplementary data
Journal Articles
Biol Open (2017) 6 (8): 1180–1189.
Published: 25 May 2017
..., biosynthetic trafficking, and ciliogenesis. Here we show that loss of function of giantin in zebrafish, using either morpholino or knockout techniques, causes defects in cilia function. Giantin morphants have fewer cilia in the neural tube and those remaining are longer. Mutants have the same number of cilia...
Includes: Supplementary data
Journal Articles
Biol Open (2016) 5 (4): 424–428.
Published: 3 March 2016
... cilia. The mutational hotspot in RPGR ORF15 is an unusual C-terminal domain encoded by exon ORF15, which is rich in polyglutamates and glycine residues (Glu-Gly domain) followed by a short stretch of basic amino acid residues (RPGR C2 domain; residues 1072-1152). However, the properties of the ORF15...
Journal Articles
Biol Open (2016) 5 (1): 20–31.
Published: 23 December 2015
...Domenico F. Galati; David S. Abuin; Gabriel A. Tauber; Andrew T. Pham; Chad G. Pearson ABSTRACT Multi-ciliated cells (MCCs) use polarized fields of undulating cilia (ciliary array) to produce fluid flow that is essential for many biological processes. Cilia are positioned by microtubule scaffolds...
Includes: Supplementary data
Journal Articles
Biol Open (2014) 3 (2): 138–151.
Published: 7 January 2014
...Teresa Mendes Maia; Delphine Gogendeau; Carole Pennetier; Carsten Janke; Renata Basto Summary Cilia and flagella are organelles essential for motility and sensing of environmental stimuli. Depending on the cell type, cilia acquire a defined set of functions and, accordingly, are built...
Includes: Supplementary data
Journal Articles
Biol Open (2013) 2 (11): 1137–1147.
Published: 11 September 2013
... that typically grows from the mother centriole in G0/G1 phase of the cell cycle as a membrane-bound compartment that protrudes from the cell surface. A unique system of bidirectional transport, intraflagellar transport (IFT), maintains the structure and function of cilia. While the axoneme is dynamic, growing...
Journal Articles
Biol Open (2012) 1 (8): 815–825.
Published: 29 June 2012
...Keishi Narita; Hiroko Kozuka-Hata; Yuta Nonami; Hiroko Ao-Kondo; Toshimitsu Suzuki; Hideki Nakamura; Kazuhiro Yamakawa; Masaaki Oyama; Takafumi Inoue; Sen Takeda Summary Cilia are structurally and functionally diverse organelles, whose malfunction leads to ciliopathies. While recent studies have...
Includes: Multimedia, Supplementary data