...Rita Brás; Augusta Monteiro; Claudio E. Sunkel; Luís Pedro Resende ABSTRACT Aneuploidy has been strongly linked to cancer development, and published evidence has suggested that aneuploidy can have an oncogenic or a tumor suppressor role depending on the tissue context. Using the Drosophila midgut...

...Jessica Patel; Seang Lin Tan; Geraldine M. Hartshorne; Andrew D. McAinsh ABSTRACT The first meiotic division in human oocytes is highly error-prone and contributes to the uniquely high incidence of aneuploidy observed in human pregnancies. A successful meiosis I (MI) division entails separation...

... cycle checkpoints, apoptosis, cellular morphology, increased aneuploidy and response to Taxol. We conclude that oncogenic effects override tissue-specific differences, at least for the mutations, tissues, and phenotypes studied herein. * Author for correspondence ( tin.su@colorado.edu...