Issues
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Cover image
Cover Image
Cover: In a study by Baral and colleagues wild-type (w1118) larval brains at 3 days old were EdU pulse labelled (Click-iT Alexa Fluor 594) for 30 min to visualize all S-phase cells: neuroblasts (NB) and ganglionic mother cells (GMCs). This merged confocal image shows EdU-labelled cells (magenta; mushroom body NBs and their GMCs) nestled within the GFP-labelled mushroom body NBs lineage (green) near the posterior regions of the central brain lobe. Scale bar: 50 microns. Image licensed under a Creative Commons Attribution 4.0 International license.
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RESEARCH ARTICLES
Methylated Vnn1 at promoter regions induces asthma occurrence via the PI3K/Akt/NFκB-mediated inflammation in IUGR mice
Summary: Vascular non-inflammatory molecule 1 (vannin-1) is elevated in intrauterine growth retardation (IUGR) asthmatic mice, leading to activation of the PI3K/Akt/NFκB pathway responsible for bronchial oxidative stress and hyperresponsiveness.
Evolutionary insights in Amazonian turtles (Testudines, Podocnemididae): co-location of 5S rDNA and U2 snRNA and wide distribution of Tc1/Mariner
Summary: This paper is important for understanding karyotype evolutionary dynamics in Amazonian turtles, focusing on physical mapping of repetitive DNA sequences.
Coupled regulations of enzymatic activity and structure formation of aldehyde dehydrogenase Ald4p
Summary: A mutation study of cytoplasmically targeted aldehyde dehydrogenase Ald4p was conducted to show that the Ald4p structure formation is coupled to the regulation of its enzymatic activity.
Nucleolar stress in Drosophila neuroblasts, a model for human ribosomopathies
Summary: Nucleolar stress (loss of ribosome production/function) in certain human progenitor or stem cells results in disease. In fruit flies, larval mushroom body neuroblasts are relatively resilient to nucleolar stress.
Abnormal expression of GABAA receptor subunits and hypomotility upon loss of gabra1 in zebrafish
Summary: By coupling human medical genetics and in vivo functional analysis we show that GABRA1 regulates motility and the expression of specific subunits of the GABAA receptor during zebrafish development.
Loss of cerebellar function selectively affects intrinsic rhythmicity of eupneic breathing
Summary: The cerebellum was believed to have no role in controlling eupneic respiration. Our findings suggest a cerebellar involvement in the coordination of breathing with other orofacial movements, such as swallowing.
Starvation causes female-to-male sex reversal through lipid metabolism in the teleost fish, medaka (Olyzias latipes)
Summary: We investigated the effects of starvation on sex differentiation in medaka. Starvation caused female-to-male sex reversal through pantothenate metabolism, fatty acid synthesis and dmrt1 expression.
A topological analysis of difference topology experiments of condensin with topoisomerase II
Summary: Tangles are used to model protein-DNA complexes. A three-dimensional ball represents protein while strings embedded in this ball represent protein-bound DNA. We used this simple model to analyze experimental results.
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