Issues

Summary: Introduction of miR-96-5p promoted proliferation, invasion and EMT of OSCC cells by directly downregulating FOXF2 expression. Hence, these findings suggested important roles for miR-96-5p/FOXF2 axis in OSCC pathogenesis and its potential application in cancer therapy.

Summary: Cellular mechanical damage is connected with the apoptosis of BMSCs, and the alterations in mechanics and nanomorphology could be used as a sensitive index to detect alterations in cell viability during apoptosis.

Summary: This work provides evidence of a novel function for a blood fluke's glycolytic enzyme (GAPDH) activating plasmin to potentially degrade blood clots, thus aiding parasite survival in the host vasculature.

Summary: High resolution traction force microscopy at single-cell level reveals the biophysical landscape of primary human myofibroblasts.

Summary: We investigated the molecular mechanism of how sal/SALL4 regulates cell invasion and found that this process depends on the dMyc-JNK pathway.

Summary: This work illustrated MACF1 function and mechanisms in regulating preosteoblast migration, which provided a possibility that MACF1 could be considered as a potential target for bone disease therapy.

Summary: Ca²⁺ dysregulation in cardiomyocytes is a common feature of cardiomyopathy and heart failure pathogenesis. Here we demonstrate in Drosophila melanogaster that store-operated Ca²⁺ entry is essential for physiological heart function.

Summary: A method for the parametric generation of three-dimensional gait based on the influence of the motion parameters and structure parameters is presented.

Summary: Sucrose consumption in liquid form predisposes rats to obesity, alters glycemic and lipid profiles, and impairs hepatic oxidative metabolism; hence, we caution against excessive consumption of artificially-sweetened beverages.