Issues
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Cover image
Cover Image
Cover: Confocal microscopy projection image of a mosaic Drosophila larval wing primordium, in which cells (green) have lost a tumor suppressor, Lgl, and simultaneously gained the transcription factor Ey, a homolog of the human PAX6 gene. Normally, Ey acts as a cell fate regulator and induces eye development. When ectopically expressed, it can induce eye formation in select development domains. This image reveals that gain of Ey can drive cancerous transformation in somatic clones displaying loss of Lgl, but only when they originate in the presumptive hinge region of the wing primordium; these transformed clones are marked by altered cytoarchitecture (actin, blue) and loss of a septate junction marker (Fas III, red). On page 1581, Gupta et al. report such selective developmental domain-specific tumor cooperation by various cell fate selectors, providing clues about their implications in human cancers. Image provided by Anjali Bajpai and licensed under a Creative Commons Attribution 4.0 International licence.
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RESEARCH ARTICLES
Selector genes display tumor cooperation and inhibition in Drosophila epithelium in a developmental context-dependent manner
Summary: This study examines the consequences of gain of cell fate selector genes in oncogenically targeted cells and reveals their two contrasting developmental context-dependent outcomes: namely, tumor cooperation and tumor inhibition.
MCAM contributes to the establishment of cell autonomous polarity in myogenic and chondrogenic differentiation
Summary: CD146/MCAM regulates cell autonomous polarization and asymmetric localization of Scribble, Van-Gogh-like 2 and Moesin, which is required in skeletal muscle myotube elongation and chondrocyte differentiation.
Characterization and analysis of CCR and CAD gene families at the whole-genome level for lignin synthesis of stone cells in pear (Pyrus bretschneideri) fruit
Summary: The characteristics of CCR and CAD families were systematically analyzed, and candidate members related to lignin synthesis and stone cell development were screened out in this study.
Release of condensin from mitotic chromosomes requires the Ran-GTP gradient in the reorganized nucleus
Summary: A mutant of Pim1/RCC1 caused hypercondensed chromatin after mitosis due to prolonged association of condensin on chromosomes, suggesting that dephosphorylation of CDK sites of condensin might require Ran-GTP after mitosis.
An evolutionarily conserved phosphatidate phosphatase maintains lipid droplet number and endoplasmic reticulum morphology but not nuclear morphology
Summary: Tetrahymena possesses two PAH homologs, TtPAH1 and TtPAH2. TtPAH1 regulates lipid droplet biogenesis and ER morphology in Tetrahymena and functionally replaces yeast PAH1.
Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion
Summary: Autophagosomes localized close to internalized collagen and focal adhesions. In autophagy-deficient cells, internalized collagen and focal adhesion were increased, focal adhesion kinase signaling was impaired, and cell adhesion was enhanced.
Cloning, molecular evolution and functional characterization of ZmbHLH16, the maize ortholog of OsTIP2 (OsbHLH142)
Summary: ZmbHLH16, the maize ortholog of OsTIP2 (OsbHLH142), its subcellular location, molecular evolution, transcriptional activity domains and heterodimerization domains with ZmbHLH51 are analyzed.
Amyloid β42 peptide is toxic to non-neural cells in Drosophila yielding a characteristic metabolite profile and the effect can be suppressed by PI3K
Summary: The Alzheimer's disease-related Aβ42 peptide is toxic for non-neural cells. This toxicity can be detected by specific metabolite changes and suppressed by the overexpression of the enzyme PI3K.
Phosphatase-regulated recruitment of the spindle- and kinetochore-associated (Ska) complex to kinetochores
Summary: Feedback between protein phosphatases and the spindle- and kinetochore-associated (Ska) complex regulates chromosome movement and the metaphase-to-anaphase cell cycle transition. This article has an associated First Person interview with the first author of the paper as part of the supplementary information.
Chlamydomonas IFT25 is dispensable for flagellar assembly but required to export the BBSome from flagella
Summary: Chlamydomonas IFT25 is not involved in flagellar assembly, but is required for export of the BBSome from the flagellum.
Light regimes differentially affect baseline transcript abundance of stress-axis and (neuro)development-related genes in zebrafish (Danio rerio, Hamilton 1822) AB and TL larvae
Summary: This study shows gene expression levels of zebrafish AB and TL larvae differ in relation to light regimes, strengthening earlier observations: AB and TL are not interchangeable strains.
Tropical Drosophila ananassae of wet-dry seasons show cross resistance to heat, drought and starvation
Summary: In the tropical Drosophila ananassae, low or high humidity-induced plastic changes in energy metabolites provide cross-protection to seasonally varying climatic stressors.
Cullin-3 and its adaptor protein ANKFY1 determine the surface level of integrin β1 in endothelial cells
Summary: CUL3 and a CUL3-binding protein ANKFY1 determined the surface expression of integrin β1, an essential adhesion molecule for angiogenesis, by regulating the endosomal recycling traffic of integrin β1.
Distribution of H3K27me3, H3K9me3, and H3K4me3 along autophagy-related genes highly expressed in starved zebrafish myotubes
Summary: The role of nuclear events in the control of autophagy is underappreciated. This study demonstrates cell starvation associated gene expression changes and autophagy-specific histone modifications.
The constant threat from a non-native predator increases tail muscle and fast-start swimming performance in Xenopus tadpoles
Summary: Xenopus tadpoles exposed to a non-native predator increase their tail length, muscle tissue and swimming speed, all of which are functionally adaptive and induced by tadpole survival behavior.
F-actin reorganization by V-ATPase inhibition in prostate cancer
Summary: V-ATPase activates multiple stress responses. In prostate cancer, sub-lethal concentrations of V-ATPase inhibitors trigger widespread traffic defects. F-actin assembles into rings that mimic those seen during regulated exocytosis.
METHODS & TECHNIQUES
Rapid isolation and expansion of skin-derived precursor cells from human primary fibroblast cultures
Summary: Exposure of human dermal fibroblast cultures to a short period of acidic stress results in rapid isolation of skin-derived precursor (SKP) cells under the three-dimensional SKP culture conditions.
Re-evaluating the functional landscape of the cardiovascular system during development
Summary: The body-wide landscape of the cardiovascular functions during development is reported. Such landscape may provide clues as to why the cardiovascular system is the first organ to develop.
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