Vestigial-dependent induction contributes to robust patterning but is not essential for wing-fate recruitment in Drosophila
Summary: Vestigial (Vg) patterning establishes wing fate in the developing wing of Drosophila. This study shows that a Vg-independent signal may drive Vg expression, but the feed-forward Vg-dependent signal is necessary for pattern sharpness and robustness.
A platform for modular assembly and feeding of micro-organoids on standard Petri dishes
Summary: Refreshing flows through organoids are required to avoid necrosis at their cores; we develop a platform for culturing micro-organoids fed by appropriate flows that is accessible to bioscientists.
Actin filaments accumulated in the nucleus remain in the vicinity of condensing chromosomes in the zebrafish early embryo
Summary: Filamentous actin accumulates in the nucleus of zebrafish early embryos and forms patches associating with condensing chromosomes during prophase.
Context-dependent thermolability of sex determination in a lacertid lizard with heteromorphic sex chromosomes
Summary: Incubation temperature influences hatchling sex in a year-dependent manner in an oviparous reptile with heteromorphic sex chromosomes.
The influence of claw morphology on gripping efficiency
Summary: By 3D printing claw shapes, we decouple the effects of geometry and materials. Through experimental testing, we show that certain claw morphologies improve grip strength more effectively than others.
The fission yeast cytokinetic ring component Fic1 promotes septum formation
Summary: The S. pombe cytokinetic ring protein Fic1 promotes septum formation in a manner dependent on interactions with the cytokinetic ring components Cdc15, Imp2, and Cyk3.
METHODS & TECHNIQUES
Bioengineering of a tumour-stroma 3D-tumouroid co-culture model of hypopharyngeal cancer
Summary: This paper describes an innovate tumour-stroma-based in vitro 3D tumouroid co-culture model of HPC developed by growing FaDu and HS-5 cells together to mimic the complex tumour microenvironment in a Petri dish. The wider application of this pre-clinical research tool is in understanding newer combination (e.g. immunotherapy) treatment approaches with radiotherapy in hypopharyngeal cancer and beyond.
Establishment of a novel protocol for formalin-fixed paraffin-embedded organoids and spheroids
Summary: Three-dimensional cell culture models such as spheroids and organoids are used in the field of experimental biology. This paper presents an optimized protocol of paraffin embedding for spheroids and organoids.
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A Year at the Forefront Review
This A Year at the Forefront Review sheds light on the most recent developments in the study of bacterial response to and defence against reactive oxygen and chlorine species. Visit our online Open Access Journal to read all about Sadia Sultana and Jan-Ulrik Dahl's work.
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