The image shows a confocal maximum projection of a Plpp3 mutant mouse embryo at 7.5 days of development with evident disorganization of the visceral endoderm (external layer). F-actin stained with falloidin-Texas red. The paper by Montané-Romero et al., explores the role of PLPP3 in pluripotency exit and endoderm differentiation of mouse embryonic stem cells. Image licensed under a Creative Commons Attribution 4.0 International license.
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Valproic acid affects neurogenesis during early optic tectum development in zebrafish
Summary: Optic tectum (OT) is a midbrain structure that is important in integrating multimodal input and guides non-voluntary movements in response to prevalent stimuli. Here we show that valproic acid, associated with autism spectrum disorder, leads to a delay in OT's neurogenesis and neuron specification.
What drives mixed-species shoaling among wild zebrafish? The roles of predators, food access, abundance of conspecifics and familiarity
Summary: In their natural habitats, zebrafish often shoal with co-occurring species. This study reveals that food apportionment, benefits related to predator avoidance and familiarity are potential drivers towards mixed-species shoaling among zebrafish.
Requirement for STAT3 and its target, TFCP2L1, in self-renewal of naïve pluripotent stem cells in vivo and in vitro
Summary: Inducing diapause in mouse embryos demonstrates that STAT3 and TFCP2L1 are essential for self-renewal of the epiblast, but only TFCP2L1 is also required for derivation of embryonic stem cells.
Plpp3, a novel regulator of pluripotency exit and endodermal differentiation of mouse embryonic stem cells
Summary: We discuss two novel roles of phospholipid phosphatase 3 (PLPP3), in pluripotency exit in mouse embryonic stem cells and in endodermal differentiation through the regulation of bioactive lipid signaling.
Sequential events during the quiescence to proliferation transition establish patterns of follicle cell differentiation in the Drosophila ovary
Summary: Epithelial follicle stem cells in the fly ovary depend on dynamic, axon-like cytoplasmic projections to re-establish cell fate patterning after a period of nutrient restriction.
Tailless and hypoxia inducible factor-2α cooperate to sustain proangiogenic states of retinal astrocytes in neonatal mice
Summary: Retinal astrocytes lose their ability to support angiogenesis as they mature. Protein–protein interaction between Tlx and HIF-2α maintains retinal astrocytes in their proangiogenic progenitor and immature states.
Establishment of a novel axon pruning model of Drosophila motor neuron
Summary: Our findings establish an unprecedented axon pruning mode that will serve to systematically screen and identify undiscovered axon pruning regulators.
A Year at the Forefront of...
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